Mouse Gene Sept9 (ENSMUST00000019038.14) Description and Page Index
  Description: Mus musculus septin 9 (Sept9), transcript variant 2, mRNA. (from RefSeq NM_001113487)
Gencode Transcript: ENSMUST00000019038.14
Gencode Gene: ENSMUSG00000059248.13
Transcript (Including UTRs)
   Position: mm10 chr11:117,266,246-117,362,313 Size: 96,068 Total Exon Count: 11 Strand: +
Coding Region
   Position: mm10 chr11:117,266,541-117,360,555 Size: 94,015 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:117,266,246-117,362,313)mRNA (may differ from genome)Protein (576 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SEPT9_MOUSE
DESCRIPTION: RecName: Full=Septin-9; AltName: Full=SL3-3 integration site 1 protein;
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
SUBUNIT: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes with actin stress fibers.
TISSUE SPECIFICITY: Expressed in all tissues examined except muscle. Isoforms are differentially expressed in testes, kidney, liver, heart, spleen and brain.
DEVELOPMENTAL STAGE: At 8 dpc mainly expressed in the lateral plate mesoderm and the somites. Beginning at 9 dpc the lateral plate expression is clearly focused in the developing fore- and hindlimb buds. In the cephalic region, expressed in the first and second branchial arch, in the nasal process and around the otic pit. At 9.5 dpc strongest expression is observed in the mesenchyme of the branchial arches, the limbs, and the developing dorsal root ganglia. Weak to intermediate expression is found in the neural epithelium. Expression is seen in the newly formed somites in the tail bud of older embryos. During formation of the digits, expression seems to outline the surviving tissue bordering it towards the apoptotic webbing. Expression is seen in the developing outer ear and in several areas known to be regulated by intensive epithelial mesenchymal interactions, like the viscera follicles and the developing mammary glands.
DISEASE: Note=Putative proto-oncogene involved in T-cell lymphomagenesis. May play a role in leukemogenesis.
MISCELLANEOUS: Targeted by proviral insertion in T-cell lymphomas induced by the murine retrovirus SL3-3 MuLV.
SIMILARITY: Belongs to the septin family.
SEQUENCE CAUTION: Sequence=BAC65697.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -159.40295-0.540 Picture PostScript Text
3' UTR -636.001758-0.362 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000038 - Cell_div_GTP-bd

Pfam Domains:
PF00735 - Septin
PF01926 - 50S ribosome-binding GTPase

SCOP Domains:
48498 - Tetracyclin repressor-like, C-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q80UG5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005525 GTP binding
GO:0045296 cadherin binding

Biological Process:
GO:0007049 cell cycle
GO:0051291 protein heterooligomerization
GO:0051301 cell division
GO:1902857 positive regulation of non-motile cilium assembly

Cellular Component:
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005930 axoneme
GO:0015629 actin cytoskeleton
GO:0031105 septin complex
GO:0048471 perinuclear region of cytoplasm
GO:0097730 non-motile cilium


-  Descriptions from all associated GenBank mRNAs
  BC046524 - Mus musculus septin 9, mRNA (cDNA clone MGC:51657 IMAGE:5290621), complete cds.
AK141312 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430026L23 product:septin 9, full insert sequence.
BC094455 - Mus musculus septin 9, mRNA (cDNA clone IMAGE:5290385), **** WARNING: chimeric clone ****.
AK122415 - Mus musculus mRNA for mKIAA0991 protein.
AJ250723 - Mus musculus mRNA for septin-like protein Sint1 (Sint1 gene).
AK170048 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630012M20 product:septin 9, full insert sequence.
AK164581 - Mus musculus 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430018O11 product:septin 9, full insert sequence.
AK031757 - Mus musculus 11 days embryo head cDNA, RIKEN full-length enriched library, clone:6230407N21 product:septin 9, full insert sequence.
AK186086 - Mus musculus cDNA, clone:Y0G0136D18, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019038, based on BLAT search.
AK211632 - Mus musculus cDNA, clone:Y2G0122F24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019038, based on BLAT search.
AK210979 - Mus musculus cDNA, clone:Y2G0120E10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019038, based on BLAT search.
AK197976 - Mus musculus cDNA, clone:Y1G0126L23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019038, based on BLAT search.
AK200886 - Mus musculus cDNA, clone:Y1G0136E20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000019038, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A6U2, A2A6U4, A2A6U6, Kiaa0991, NM_001113487, Q3URP2, Q80TM7, Q80UG5, Q9QYX9, SEPT9_MOUSE, Sint1, uc007mne.1, uc007mne.2, uc007mne.3
UCSC ID: uc007mne.3
RefSeq Accession: NM_001113487
Protein: Q80UG5 (aka SEPT9_MOUSE)
CCDS: CCDS48991.1, CCDS48990.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.