Mouse Gene Nufip2 (ENSMUST00000100802.10) Description and Page Index
  Description: Mus musculus nuclear fragile X mental retardation protein interacting protein 2 (Nufip2), mRNA. (from RefSeq NM_001024205)
Gencode Transcript: ENSMUST00000100802.10
Gencode Gene: ENSMUSG00000037857.16
Transcript (Including UTRs)
   Position: mm10 chr11:77,686,155-77,712,741 Size: 26,587 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr11:77,686,228-77,709,735 Size: 23,508 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:77,686,155-77,712,741)mRNA (may differ from genome)Protein (692 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NUFP2_MOUSE
DESCRIPTION: RecName: Full=Nuclear fragile X mental retardation-interacting protein 2; AltName: Full=82 kDa FMRP-interacting protein; Short=82-FIP; AltName: Full=FMRP-interacting protein 2;
FUNCTION: Binds RNA (By similarity).
SUBUNIT: Interacts with FMRP (By similarity).
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most neurons. In the cortex, distributed in a diffuse way in the nucleus and in the cytoplasm. Localized in the cytoplasm in neurons of the dentate gyrus in the olfactive bulb, in the ependymal epithelium and in the granular layer of the cerebellum. In Purkinje cells, distributed in both cell compartments and in nuclear dots adjacent to the nucleolus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SEQUENCE CAUTION: Sequence=BAC65776.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.7073-0.270 Picture PostScript Text
3' UTR -753.243006-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15293 - Nuclear fragile X mental retardation-interacting protein 2

ModBase Predicted Comparative 3D Structure on Q5F2E7
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016604 nuclear body
GO:0042788 polysomal ribosome


-  Descriptions from all associated GenBank mRNAs
  AK132603 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833415L12 product:FMRP interacting protein, 82kD homolog [Homo sapiens], full insert sequence.
AK160601 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610017I04 product:FMRP interacting protein, 82kD homolog [Homo sapiens], full insert sequence.
AK030113 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4932442O22 product:FMRP interacting protein, 82kD homolog [Homo sapiens], full insert sequence.
AK170764 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630118O11 product:FMRP interacting protein, 82kD homolog [Homo sapiens], full insert sequence.
AK122494 - Mus musculus mRNA for mKIAA1321 protein.
AK152336 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830063B10 product:FMRP interacting protein, 82kD homolog [Homo sapiens], full insert sequence.
AK142954 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030017F08 product:FMRP interacting protein, 82kD homolog [Homo sapiens], full insert sequence.
BC141543 - Synthetic construct Mus musculus clone IMAGE:100014536, MGC:175406 nuclear fragile X mental retardation protein interacting protein 2 (Nufip2) mRNA, encodes complete protein.
DQ724886 - Mus musculus piRNA piR-140208, complete sequence.
AK003251 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110001M19 product:unclassifiable, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: Kiaa1321, NM_001024205, NUFP2_MOUSE, Q3TCE2, Q3V195, Q5F2E7, Q80TF1, uc007khd.1, uc007khd.2, uc007khd.3
UCSC ID: uc007khd.3
RefSeq Accession: NM_001024205
Protein: Q5F2E7 (aka NUFP2_MOUSE)
CCDS: CCDS25083.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.