Mouse Gene Cct4 (ENSMUST00000173867.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus chaperonin containing Tcp1, subunit 4 (delta) (Cct4), mRNA. (from RefSeq NM_009837)
Gencode Transcript: ENSMUST00000173867.7
Gencode Gene: ENSMUSG00000007739.10
Transcript (Including UTRs)
   Position: mm10 chr11:22,990,519-23,003,780 Size: 13,262 Total Exon Count: 14 Strand: +
Coding Region
   Position: mm10 chr11:22,990,754-23,003,151 Size: 12,398 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:22,990,519-23,003,780)mRNA (may differ from genome)Protein (539 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q564F4_MOUSE
DESCRIPTION: RecName: Full=T-complex protein 1 subunit delta;
SIMILARITY: Belongs to the TCP-1 chaperonin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.80235-0.386 Picture PostScript Text
3' UTR -158.40629-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012717 - Chap_CCT_delta
IPR017998 - Chaperone_TCP-1
IPR002194 - Chaperonin_TCP-1_CS
IPR002423 - Cpn60/TCP-1

Pfam Domains:
PF00118 - TCP-1/cpn60 chaperonin family

SCOP Domains:
48592 - GroEL equatorial domain-like
52029 - GroEL apical domain-like
54849 - GroEL-intermediate domain like

ModBase Predicted Comparative 3D Structure on Q564F4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding

Biological Process:
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051973 positive regulation of telomerase activity
GO:0090666 scaRNA localization to Cajal body
GO:1901998 toxin transport
GO:1904851 positive regulation of establishment of protein localization to telomere
GO:1904874 positive regulation of telomerase RNA localization to Cajal body

Cellular Component:
GO:0002199 zona pellucida receptor complex
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0044297 cell body


-  Descriptions from all associated GenBank mRNAs
  Z31554 - M.musculus (129/Sv) Cctd mRNA for CCT (chaperonin containing TCP-1) delta subunit.
AK146242 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730039L03 product:chaperonin subunit 4 (delta), full insert sequence.
AK010634 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410038N06 product:chaperonin subunit 4 (delta), full insert sequence.
AK152665 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830082B11 product:chaperonin subunit 4 (delta), full insert sequence.
AK165229 - Mus musculus 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F420013F22 product:chaperonin subunit 4 (delta), full insert sequence.
AK167026 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0028D03 product:chaperonin subunit 4 (delta), full insert sequence.
BC054773 - Mus musculus chaperonin containing Tcp1, subunit 4 (delta), mRNA (cDNA clone MGC:65609 IMAGE:6807250), complete cds.
AK163369 - Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020023P15 product:chaperonin subunit 4 (delta), full insert sequence.
AK150601 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830012K01 product:chaperonin subunit 4 (delta), full insert sequence.
AK152173 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830053H18 product:chaperonin subunit 4 (delta), full insert sequence.
AK169339 - Mus musculus 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920187K10 product:chaperonin subunit 4 (delta), full insert sequence.
AK167657 - Mus musculus 12 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530027F15 product:chaperonin subunit 4 (delta), full insert sequence.
AK167846 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730032I04 product:chaperonin subunit 4 (delta), full insert sequence.
AK167262 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0047K05 product:chaperonin subunit 4 (delta), full insert sequence.
L25913 - Mus musculus chaperonin mRNA, complete cds.
AK200879 - Mus musculus cDNA, clone:Y1G0136E12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK206188 - Mus musculus cDNA, clone:Y2G0104A15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK208716 - Mus musculus cDNA, clone:Y2G0112I07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK215884 - Mus musculus cDNA, clone:Y2G0136H20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK219961 - Mus musculus cDNA, clone:Y2G0150E14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK213770 - Mus musculus cDNA, clone:Y2G0129G18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK219702 - Mus musculus cDNA, clone:Y2G0149F06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK207154 - Mus musculus cDNA, clone:Y2G0107B17, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK207215 - Mus musculus cDNA, clone:Y2G0107E22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK213345 - Mus musculus cDNA, clone:Y2G0128A22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK088703 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430024B07 product:chaperonin subunit 4 (delta), full insert sequence.
AK214188 - Mus musculus cDNA, clone:Y2G0130P14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK194972 - Mus musculus cDNA, clone:Y1G0116P18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000020562, based on BLAT search.
AK014251 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110073C03 product:unclassifiable, full insert sequence.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
m_bcellsurvivalPathway - B Cell Survival Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_8764, NM_009837, Q564F4, Q564F4_MOUSE, RP24-143D17.2-001, uc007ieo.1, uc007ieo.2
UCSC ID: uc007ieo.2
RefSeq Accession: NM_009837
Protein: Q564F4 CCDS: CCDS24474.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.