Mouse Gene Brinp2 (ENSMUST00000004133.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus bone morphogenic protein/retinoic acid inducible neural-specific 2 (Brinp2), mRNA. (from RefSeq NM_207583)
Gencode Transcript: ENSMUST00000004133.10
Gencode Gene: ENSMUSG00000004031.13
Transcript (Including UTRs)
   Position: mm10 chr1:158,245,269-158,356,326 Size: 111,058 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr1:158,246,198-158,295,694 Size: 49,497 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-20

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:158,245,269-158,356,326)mRNA (may differ from genome)Protein (783 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FAM5B_MOUSE
DESCRIPTION: RecName: Full=Protein FAM5B; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the FAM5 family.
SIMILARITY: Contains 1 MACPF domain.
SEQUENCE CAUTION: Sequence=BAC65831.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -352.20886-0.398 Picture PostScript Text
3' UTR -295.70929-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR020864 - MACPF

Pfam Domains:
PF01823 - MAC/Perforin domain

SCOP Domains:
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q6DFY8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0007049 cell cycle
GO:0007050 cell cycle arrest
GO:0045666 positive regulation of neuron differentiation
GO:0045786 negative regulation of cell cycle
GO:0045930 negative regulation of mitotic cell cycle
GO:0071300 cellular response to retinoic acid

Cellular Component:
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0030425 dendrite
GO:0043025 neuronal cell body


-  Descriptions from all associated GenBank mRNAs
  AK032297 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430517E21 product:hypothetical Membrane attack complex components/perforin/complement C9 containing protein, full insert sequence.
BC067038 - Mus musculus RIKEN cDNA 6430517E21 gene, mRNA (cDNA clone IMAGE:6840309), partial cds.
AK122549 - Mus musculus mRNA for mKIAA1747 protein.
BC076572 - Mus musculus family with sequence similarity 5, member B, mRNA (cDNA clone MGC:100244 IMAGE:30363878), complete cds.
AK045801 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230311I04 product:hypothetical FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase), Membrane attack complex components/perforin/complement C9 containing protein, full insert sequence.
AK047824 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130002B21 product:unclassifiable, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: Fam5b, FAM5B_MOUSE, Kiaa1747, NM_207583, Q6DFY8, Q80T96, uc007ddq.1, uc007ddq.2, uc007ddq.3
UCSC ID: uc007ddq.3
RefSeq Accession: NM_207583
Protein: Q6DFY8 (aka FAM5B_MOUSE)
CCDS: CCDS15401.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.