ID:WLS_MOUSE DESCRIPTION: RecName: Full=Protein wntless homolog; AltName: Full=Integral membrane protein GPR177; AltName: Full=Protein evenness interrupted homolog; Short=EVI; Flags: Precursor; FUNCTION: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. SUBUNIT: Interacts with WNT3A (By similarity). Interacts with WNT1, WNT3 and WNT5. SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in kidney, lung, skin, intestine, brain, spinal cord, skeleton, eyes, excretion glands, tooth and palatal shelves. DEVELOPMENTAL STAGE: Detected at E6.25 in the proximal epiblast at the junction between the embryonic and extraembryonic tissue. Later expression is more restricted to the primitive streak and mesoderm extending to the distal tip of the embryo. Strong expression is found in both posterior visceral endoderm and epiblast at the prestreak, but switched to the mesoderm at late- streak. INDUCTION: Up-regulated by WNT1. Transcriptionally activated by beta-catenin and by LEF/TCF-dependent transcription. DISRUPTION PHENOTYPE: Mice display embryonic lethality before E10.5. Embryos show defects in the establishment of the body axis and in the primitive streak and mesoderm formation. SIMILARITY: Belongs to the wntless family. SEQUENCE CAUTION: Sequence=AAH18381.1; Type=Erroneous initiation; Sequence=BAC26266.1; Type=Erroneous initiation; Sequence=BAC26300.1; Type=Erroneous initiation; Sequence=BAC32102.1; Type=Erroneous initiation; Sequence=BAC33950.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06664 - Wnt-binding factor required for Wnt secretion
ModBase Predicted Comparative 3D Structure on Q6DID7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
