Mouse Gene Dclk2 (ENSMUST00000029719.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus doublecortin-like kinase 2 (Dclk2), transcript variant 2, mRNA. (from RefSeq NM_027539) RefSeq Summary (NM_027539): This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]. Gencode Transcript: ENSMUST00000029719.13 Gencode Gene: ENSMUSG00000028078.14 Transcript (Including UTRs) Position: mm10 chr3:86,786,153-86,920,852 Size: 134,700 Total Exon Count: 16 Strand: - Coding Region Position: mm10 chr3:86,787,212-86,920,170 Size: 132,959 Coding Exon Count: 16
ID:DCLK2_MOUSE DESCRIPTION: RecName: Full=Serine/threonine-protein kinase DCLK2; EC=2.7.11.1; AltName: Full=CaMK-like CREB regulatory kinase 2; Short=CL2; Short=CLICK-II; Short=CLICK2; AltName: Full=Doublecortin-like and CAM kinase-like 2; AltName: Full=Doublecortin-like kinase 2; FUNCTION: Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Binds to and stabilizes microtubules (By similarity). Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. TISSUE SPECIFICITY: Expressed in the central and peripheral nervous system including the brain, spinal cord, cranial and dorsal root ganglia and in the parasympathetic ganglia. Present in neurons, but not in glial cells, in most forebrain areas. Strong expression in the hippocampal CA1 pyramidal cell layer. Expressed in the photoreceptor sensory cilium complex and in eyes. Also detected in individual cells of the olfactory epithelium. DEVELOPMENTAL STAGE: At 17.5 dpc, predominantly expressed in the central nervous system, throughout the forebrain, midbrain, hindbrain, and the spinal cord. Expressed in the developing neocortex and at low levels in the ventricular zone, especially in the outer neuroblastic layer. In the developing retina, strongly expressed in the postmitotic inner neuroblastic layer. Also found in the developing ovary and, to a lower extent, throughout the kidney. DOMAIN: The doublecortin domains are involved in the colocalization with microtubules. PTM: Autophosphorylated (By similarity). DISRUPTION PHENOTYPE: Frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. SIMILARITY: Contains 2 doublecortin domains. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6PGN3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
