ID:PKHB2_MOUSE DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family B member 2; Short=PH domain-containing family B member 2; AltName: Full=Evectin-2; FUNCTION: Involved in retrograde transport of recycling endosomes (By similarity). SUBCELLULAR LOCATION: Recycling endosome membrane (By similarity); Peripheral membrane protein. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR (By similarity). TISSUE SPECIFICITY: Highly expressed in brain, retina, heart and kidney. Detected at lower levels in lung, muscle and nerve. DEVELOPMENTAL STAGE: Highly expressed at birth and up to day 3; expressed at lower levels in embryo and adult. DOMAIN: The PH domain specifically binds phosphatidylserine, which is enriched in recycling endosome membranes, it doesn't recognize PIPs (By similarity). SIMILARITY: Contains 1 PH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9QZC7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
