ID:RFIP2_HUMAN DESCRIPTION: RecName: Full=Rab11 family-interacting protein 2; Short=Rab11-FIP2; AltName: Full=NRip11; FUNCTION: A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. SUBUNIT: Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with RAB11A/RAB11B that has been activated by GTP binding. Interacts with NPC1L1. INTERACTION: P62491:RAB11A; NbExp=2; IntAct=EBI-1049676, EBI-745098; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. PTM: Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 FIP-RBD domain. SEQUENCE CAUTION: Sequence=BAA76785.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7L804
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003091 renal water homeostasis GO:0015031 protein transport GO:0030010 establishment of cell polarity GO:0035773 insulin secretion involved in cellular response to glucose stimulus GO:0045055 regulated exocytosis GO:1903078 positive regulation of protein localization to plasma membrane
AB023158 - Homo sapiens KIAA0941 mRNA for KIAA0941 protein. AY037299 - Homo sapiens nRip11 mRNA, complete cds. BX647717 - Homo sapiens mRNA; cDNA DKFZp686L10277 (from clone DKFZp686L10277). JD410882 - Sequence 391906 from Patent EP1572962. JD273915 - Sequence 254939 from Patent EP1572962. JD317156 - Sequence 298180 from Patent EP1572962. JD410902 - Sequence 391926 from Patent EP1572962. JD416534 - Sequence 397558 from Patent EP1572962. JD300763 - Sequence 281787 from Patent EP1572962. JD090868 - Sequence 71892 from Patent EP1572962. JD237510 - Sequence 218534 from Patent EP1572962. JD352352 - Sequence 333376 from Patent EP1572962. JD273757 - Sequence 254781 from Patent EP1572962. JD281224 - Sequence 262248 from Patent EP1572962. JD531137 - Sequence 512161 from Patent EP1572962. JD345329 - Sequence 326353 from Patent EP1572962. JD494921 - Sequence 475945 from Patent EP1572962. JD552740 - Sequence 533764 from Patent EP1572962. JD236412 - Sequence 217436 from Patent EP1572962. JD538571 - Sequence 519595 from Patent EP1572962. JD511064 - Sequence 492088 from Patent EP1572962. JD180923 - Sequence 161947 from Patent EP1572962. JD504085 - Sequence 485109 from Patent EP1572962. JD262720 - Sequence 243744 from Patent EP1572962. JD437164 - Sequence 418188 from Patent EP1572962. JD046599 - Sequence 27623 from Patent EP1572962. JD226014 - Sequence 207038 from Patent EP1572962. JD267558 - Sequence 248582 from Patent EP1572962. JD561975 - Sequence 542999 from Patent EP1572962. JD345300 - Sequence 326324 from Patent EP1572962. JD073314 - Sequence 54338 from Patent EP1572962. BC075073 - Homo sapiens RAB11 family interacting protein 2 (class I), mRNA (cDNA clone MGC:104137 IMAGE:30915593), complete cds. BC075074 - Homo sapiens RAB11 family interacting protein 2 (class I), mRNA (cDNA clone MGC:103973 IMAGE:30915380), complete cds. DQ013303 - Homo sapiens RAB11-FIP2 long isoform mRNA, complete cds, alternatively spliced. AB384053 - Synthetic construct DNA, clone: pF1KSDA0941, Homo sapiens RAB11FIP2 gene for RAB11 family-interacting protein 2, complete cds, without stop codon, in Flexi system. KJ898414 - Synthetic construct Homo sapiens clone ccsbBroadEn_07808 RAB11FIP2 gene, encodes complete protein. JD317872 - Sequence 298896 from Patent EP1572962. JD396956 - Sequence 377980 from Patent EP1572962. JD520843 - Sequence 501867 from Patent EP1572962. JD131545 - Sequence 112569 from Patent EP1572962. JD074957 - Sequence 55981 from Patent EP1572962. JD179163 - Sequence 160187 from Patent EP1572962. JD474822 - Sequence 455846 from Patent EP1572962. JD471708 - Sequence 452732 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis
Reactome (by CSHL, EBI, and GO)
Protein Q7L804 (Reactome details) participates in the following event(s):
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-445717 Aquaporin-mediated transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
