ID:PLRG1_MOUSE DESCRIPTION: RecName: Full=Pleiotropic regulator 1; FUNCTION: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity). SUBUNIT: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Also interacts directly in the complex with BCAS2 and PRPF19 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus speckle (By similarity). SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. SIMILARITY: Contains 7 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q922V4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03040 - Spliceosome
Reactome (by CSHL, EBI, and GO)
Protein Q922V4 (Reactome details) participates in the following event(s):
R-MMU-72127 Formation of the Spliceosomal B Complex R-MMU-72139 Formation of the active Spliceosomal C (B*) complex R-MMU-72143 Lariat Formation and 5'-Splice Site Cleavage R-MMU-156661 Formation of Exon Junction Complex R-MMU-72163 mRNA Splicing - Major Pathway R-MMU-72172 mRNA Splicing R-MMU-72203 Processing of Capped Intron-Containing Pre-mRNA R-MMU-8953854 Metabolism of RNA
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Sequence and Links to Tools and Databases 
