ID:PLAP_MOUSE DESCRIPTION: RecName: Full=Phospholipase A-2-activating protein; Short=PLA2P; Short=PLAP; FUNCTION: Involved in the maintenance of ubiquitin levels (By similarity). SUBUNIT: Interacts with ubiquitin. Interacts with VCP (By similarity). INDUCTION: In smooth muscle and endothelial cells by leukotriene D4, by tumor necrosis factor in endothelial cells and by uric acid crystals in macrophages. DOMAIN: The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus (By similarity). DOMAIN: The PFU domain mediates interaction with ubiquitin (By similarity). SIMILARITY: Belongs to the WD repeat PLAP family. SIMILARITY: Contains 6 ARM repeats. SIMILARITY: Contains 1 PFU domain. SIMILARITY: Contains 1 PUL domain. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=AAA39943.1; Type=Miscellaneous discrepancy; Note=Several frameshifts and contaminating sequence; Sequence=Ref.3; Type=Frameshift; Positions=697;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27612
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006693 prostaglandin metabolic process GO:0006954 inflammatory response GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0010992 ubiquitin homeostasis GO:0016236 macroautophagy GO:0032430 positive regulation of phospholipase A2 activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0071222 cellular response to lipopolysaccharide GO:1900045 negative regulation of protein K63-linked ubiquitination GO:1903423 positive regulation of synaptic vesicle recycling GO:1903861 positive regulation of dendrite extension GO:2001224 positive regulation of neuron migration
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Sequence and Links to Tools and Databases 
