Description: Homo sapiens inhibin, beta C (INHBC), mRNA. RefSeq Summary (NM_005538): This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr12:57,828,543-57,844,609 Size: 16,067 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr12:57,828,670-57,843,805 Size: 15,136 Coding Exon Count: 2
ID:INHBC_HUMAN DESCRIPTION: RecName: Full=Inhibin beta C chain; AltName: Full=Activin beta-C chain; Flags: Precursor; FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. SUBUNIT: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity). SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Expressed in benign prostatic hyperplasia. SIMILARITY: Belongs to the TGF-beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55103
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0010469 regulation of receptor activity GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0042981 regulation of apoptotic process GO:0043408 regulation of MAPK cascade GO:0048468 cell development GO:0060395 SMAD protein signal transduction
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
AK314849 - Homo sapiens cDNA, FLJ95746, highly similar to Homo sapiens inhibin, beta C (INHBC), mRNA. BC020693 - Homo sapiens cDNA clone IMAGE:4723762. X82540 - H.sapiens mRNA for activin beta-C chain. BC130324 - Homo sapiens inhibin, beta C, mRNA (cDNA clone MGC:163196 IMAGE:40146355), complete cds. BC130326 - Homo sapiens inhibin, beta C, mRNA (cDNA clone MGC:163198 IMAGE:40146357), complete cds. JD467558 - Sequence 448582 from Patent EP1572962. AB590801 - Synthetic construct DNA, clone: pFN21AE1834, Homo sapiens INHBC gene for inhibin, beta C, without stop codon, in Flexi system. KJ891478 - Synthetic construct Homo sapiens clone ccsbBroadEn_00872 INHBC gene, encodes complete protein. JD486772 - Sequence 467796 from Patent EP1572962. JD226321 - Sequence 207345 from Patent EP1572962. DQ588265 - Homo sapiens piRNA piR-55377, complete sequence. JD321687 - Sequence 302711 from Patent EP1572962. JD248115 - Sequence 229139 from Patent EP1572962. JD516859 - Sequence 497883 from Patent EP1572962. JD562279 - Sequence 543303 from Patent EP1572962. JD566151 - Sequence 547175 from Patent EP1572962. JD429000 - Sequence 410024 from Patent EP1572962. JD193672 - Sequence 174696 from Patent EP1572962. JD444244 - Sequence 425268 from Patent EP1572962. JD416122 - Sequence 397146 from Patent EP1572962. JD393791 - Sequence 374815 from Patent EP1572962. JD519513 - Sequence 500537 from Patent EP1572962. JD411679 - Sequence 392703 from Patent EP1572962. JD391243 - Sequence 372267 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04350 - TGF-beta signaling pathway
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