Human Gene LMTK2 (ENST00000297293.6) from GENCODE V44
Description: Homo sapiens lemur tyrosine kinase 2 (LMTK2), mRNA. (from RefSeq NM_014916) RefSeq Summary (NM_014916): The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000297293.6 Gencode Gene: ENSG00000164715.6 Transcript (Including UTRs) Position: hg38 chr7:98,106,862-98,209,638 Size: 102,777 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr7:98,107,178-98,205,492 Size: 98,315 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IWU2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001881 receptor recycling GO:0006468 protein phosphorylation GO:0016310 phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0032456 endocytic recycling GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0033572 transferrin transport GO:0045022 early endosome to late endosome transport GO:0046777 protein autophosphorylation
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