Human Gene RAB9B (ENST00000243298.3) from GENCODE V44
Description: Homo sapiens RAB9B, member RAS oncogene family (RAB9B), transcript variant 1, mRNA. (from RefSeq NM_016370) RefSeq Summary (NM_016370): This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]. Gencode Transcript: ENST00000243298.3 Gencode Gene: ENSG00000123570.4 Transcript (Including UTRs) Position: hg38 chrX:103,822,327-103,832,257 Size: 9,931 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chrX:103,825,179-103,825,784 Size: 606 Coding Exon Count: 1
ID:RAB9B_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-9B; AltName: Full=Rab-9-like protein; Short=Rab-9L; FUNCTION: Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NP90
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC018033 - Homo sapiens RAB9B, member RAS oncogene family, mRNA (cDNA clone IMAGE:4800052). BC041336 - Homo sapiens cDNA clone IMAGE:5274429, containing frame-shift errors. BC070069 - Homo sapiens cDNA clone IMAGE:5261286, containing frame-shift errors. AB036693 - Homo sapiens mRNA for RAB9-like protein, complete cds. JD043989 - Sequence 25013 from Patent EP1572962. BC093758 - Homo sapiens RAB9B, member RAS oncogene family, mRNA (cDNA clone MGC:120793 IMAGE:7939603), complete cds. BC093756 - Homo sapiens RAB9B, member RAS oncogene family, mRNA (cDNA clone MGC:120791 IMAGE:7939601), complete cds. JD230404 - Sequence 211428 from Patent EP1572962. JD282109 - Sequence 263133 from Patent EP1572962. JD282108 - Sequence 263132 from Patent EP1572962. AK313425 - Homo sapiens cDNA, FLJ93964, Homo sapiens RAB9B, member RAS oncogene family (RAB9B), mRNA. KJ893852 - Synthetic construct Homo sapiens clone ccsbBroadEn_03246 RAB9B gene, encodes complete protein. AB464683 - Synthetic construct DNA, clone: pF1KB8759, Homo sapiens RAB9B gene for RAB9B, member RAS oncogene family, without stop codon, in Flexi system. JD154208 - Sequence 135232 from Patent EP1572962. JD056771 - Sequence 37795 from Patent EP1572962. JD203519 - Sequence 184543 from Patent EP1572962. JD339226 - Sequence 320250 from Patent EP1572962. JD177945 - Sequence 158969 from Patent EP1572962. JD532861 - Sequence 513885 from Patent EP1572962. JD471695 - Sequence 452719 from Patent EP1572962. JD116084 - Sequence 97108 from Patent EP1572962. JD546735 - Sequence 527759 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NP90 (Reactome details) participates in the following event(s):
R-HSA-6798743 Exocytosis of secretory granule membrane proteins R-HSA-8870466 RGGT:CHM binds RABs R-HSA-8876191 RAB9 GEFs exchange GTP for GDP on RAB9 R-HSA-8870469 RGGT geranylgeranylates RAB proteins R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins R-HSA-6814670 ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation R-HSA-6814675 RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN R-HSA-6798695 Neutrophil degranulation R-HSA-168249 Innate Immune System R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-8873719 RAB geranylgeranylation R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs R-HSA-168256 Immune System R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-597592 Post-translational protein modification R-HSA-9007101 Rab regulation of trafficking R-HSA-199991 Membrane Trafficking R-HSA-392499 Metabolism of proteins R-HSA-5653656 Vesicle-mediated transport
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