Human Gene NOL11 (uc002jgd.1)
  Description: Homo sapiens nucleolar protein 11 (NOL11), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:65,714,061-65,740,266 Size: 26,206 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr17:65,714,064-65,739,975 Size: 25,912 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:65,714,061-65,740,266)mRNA (may differ from genome)Protein (719 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NOL11_HUMAN
DESCRIPTION: RecName: Full=Nucleolar protein 11;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SEQUENCE CAUTION: Sequence=CAB53709.1; Type=Frameshift; Positions=382, 383;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.89 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 504.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -75.80291-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012584 - NUC205

Pfam Domains:
PF08168 - NUC205 domain

ModBase Predicted Comparative 3D Structure on Q9H8H0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0034455 t-UTP complex


-  Descriptions from all associated GenBank mRNAs
  BC064404 - Homo sapiens nucleolar protein 11, mRNA (cDNA clone MGC:74641 IMAGE:5555907), complete cds.
AK023702 - Homo sapiens cDNA FLJ13640 fis, clone PLACE1011221.
LF384814 - JP 2014500723-A/192317: Polycomb-Associated Non-Coding RNAs.
AK299483 - Homo sapiens cDNA FLJ55361 complete cds, highly similar to Nucleolar protein 11.
AY598333 - Homo sapiens L14 mRNA, complete cds.
AL110271 - Homo sapiens mRNA; cDNA DKFZp586L0724 (from clone DKFZp586L0724).
LF328325 - JP 2014500723-A/135828: Polycomb-Associated Non-Coding RNAs.
DL492229 - Novel nucleic acids.
BC001726 - Homo sapiens nucleolar protein 11, mRNA (cDNA clone IMAGE:3534516), partial cds.
AK025390 - Homo sapiens cDNA: FLJ21737 fis, clone COLF3396.
LF328323 - JP 2014500723-A/135826: Polycomb-Associated Non-Coding RNAs.
LF328321 - JP 2014500723-A/135824: Polycomb-Associated Non-Coding RNAs.
LF328319 - JP 2014500723-A/135822: Polycomb-Associated Non-Coding RNAs.
JD244505 - Sequence 225529 from Patent EP1572962.
JD308461 - Sequence 289485 from Patent EP1572962.
LF328318 - JP 2014500723-A/135821: Polycomb-Associated Non-Coding RNAs.
JD320299 - Sequence 301323 from Patent EP1572962.
MA620391 - JP 2018138019-A/192317: Polycomb-Associated Non-Coding RNAs.
MA563902 - JP 2018138019-A/135828: Polycomb-Associated Non-Coding RNAs.
MA563900 - JP 2018138019-A/135826: Polycomb-Associated Non-Coding RNAs.
MA563898 - JP 2018138019-A/135824: Polycomb-Associated Non-Coding RNAs.
MA563896 - JP 2018138019-A/135822: Polycomb-Associated Non-Coding RNAs.
MA563895 - JP 2018138019-A/135821: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H8H0 (Reactome details) participates in the following event(s):

R-HSA-6790906 EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-72312 rRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: L14, NM_015462, NOL11_HUMAN, NP_056277, Q7L5S1, Q9H8H0, Q9UG18
UCSC ID: uc002jgd.1
RefSeq Accession: NM_015462
Protein: Q9H8H0 (aka NOL11_HUMAN)
CCDS: CCDS11671.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015462.3
exon count: 18CDS single in 3' UTR: no RNA size: 2454
ORF size: 2160CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4424.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.