Mouse Gene Ska3 (ENSMUST00000022536.2) Description and Page Index
  Description: Mus musculus spindle and kinetochore associated complex subunit 3 (Ska3), mRNA. (from RefSeq NM_198605)
Gencode Transcript: ENSMUST00000022536.2
Gencode Gene: ENSMUSG00000021965.3
Transcript (Including UTRs)
   Position: mm10 chr14:57,806,561-57,826,163 Size: 19,603 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr14:57,807,977-57,826,112 Size: 18,136 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2019-09-20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:57,806,561-57,826,163)mRNA (may differ from genome)Protein (411 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Spindle and kinetochore-associated protein 3;
FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization (By similarity).
SUBUNIT: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle (By similarity). Chromosome, centromere, kinetochore (By similarity). Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner (By similarity).
SIMILARITY: Belongs to the SKA3 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.9051-0.312 Picture PostScript Text
3' UTR -282.80973-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8C263
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0000278 mitotic cell cycle
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0051301 cell division

Cellular Component:
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000940 condensed chromosome outer kinetochore
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule

-  Descriptions from all associated GenBank mRNAs
  AK089223 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630043A04 product:hypothetical protein, full insert sequence.
AK213217 - Mus musculus cDNA, clone:Y2G0127J19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022536, based on BLAT search.
AK166171 - Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830003C03 product:weakly similar to RAMA1 [Homo sapiens], full insert sequence.
BC117500 - Mus musculus RIKEN cDNA F630043A04 gene, mRNA (cDNA clone MGC:144780 IMAGE:40105921), complete cds.
BC117501 - Mus musculus RIKEN cDNA F630043A04 gene, mRNA (cDNA clone MGC:144779 IMAGE:40105920), complete cds.
AK199129 - Mus musculus cDNA, clone:Y1G0130E03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022536, based on BLAT search.
AK217625 - Mus musculus cDNA, clone:Y2G0142G11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022536, based on BLAT search.
AK158142 - Mus musculus adult inner ear cDNA, RIKEN full-length enriched library, clone:F930035E19 product:weakly similar to RAMA1 [Homo sapiens], full insert sequence.
AK204412 - Mus musculus cDNA, clone:Y1G0148F11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022536, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_198605, Q149T5, Q149T6, Q8C263, Rama1, SKA3_MOUSE, uc007udp.1
UCSC ID: uc007udp.1
RefSeq Accession: NM_198605
Protein: Q8C263 (aka SKA3_MOUSE)
CCDS: CCDS27160.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.