Description: Homo sapiens GTP binding protein 1 (GTPBP1), mRNA. RefSeq Summary (NM_004286): This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr22:39,101,807-39,129,592 Size: 27,786 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr22:39,101,961-39,126,709 Size: 24,749 Coding Exon Count: 12
ID:GTPB1_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein 1; Short=G-protein 1; Short=GP-1; Short=GP1; FUNCTION: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). SUBUNIT: Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Belongs to the GTPBP1 GTP-binding protein family. SEQUENCE CAUTION: Sequence=AAB51273.1; Type=Erroneous initiation; Sequence=CAG30387.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00178
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006955 immune response GO:0007165 signal transduction GO:0046039 GTP metabolic process GO:0061014 positive regulation of mRNA catabolic process
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