Description: Homo sapiens minichromosome maintenance complex component 3 associated protein (MCM3AP), mRNA. RefSeq Summary (NM_003906): The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]. Transcript (Including UTRs) Position: hg19 chr21:47,655,048-47,705,236 Size: 50,189 Total Exon Count: 28 Strand: - Coding Region Position: hg19 chr21:47,655,182-47,705,200 Size: 50,019 Coding Exon Count: 28
ID:MCM3A_HUMAN DESCRIPTION: RecName: Full=80 kDa MCM3-associated protein; AltName: Full=Protein GANP; FUNCTION: May be involved in the nuclear localization pathway of MCM3. SUBUNIT: Interacts with MCM3. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the SAC3 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mcm3ap/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03399 - SAC3/GANP family PF16766 - Binding region of GANP to ENY2 PF16768 - Nucleoporin homology of Germinal-centre associated nuclear protein PF16769 - MCM3AP domain of GANP
ModBase Predicted Comparative 3D Structure on O60318
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
