Description: Homo sapiens COP9 signalosome subunit 5 (COPS5), mRNA. RefSeq Summary (NM_006837): The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:67,955,315-67,974,562 Size: 19,248 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr8:67,955,468-67,974,231 Size: 18,764 Coding Exon Count: 8
ID:CSN5_HUMAN DESCRIPTION: RecName: Full=COP9 signalosome complex subunit 5; Short=SGN5; Short=Signalosome subunit 5; EC=3.4.-.-; AltName: Full=Jun activation domain-binding protein 1; FUNCTION: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. COFACTOR: Divalent metal ions (By similarity). SUBUNIT: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. INTERACTION: O95273:CCNDBP1; NbExp=5; IntAct=EBI-594661, EBI-748961; P46527:CDKN1B; NbExp=3; IntAct=EBI-594661, EBI-519280; P55085:F2RL1; NbExp=8; IntAct=EBI-594661, EBI-4303189; Q9H8M7:FAM188A; NbExp=3; IntAct=EBI-594661, EBI-724928; O15105:SMAD7; NbExp=10; IntAct=EBI-594661, EBI-3861591; P10599:TXN; NbExp=8; IntAct=EBI-594661, EBI-594644; P09936:UCHL1; NbExp=3; IntAct=EBI-594661, EBI-714860; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear localization is diminished in the presence of IFIT3. DOMAIN: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity). MISCELLANEOUS: The CSN complex is associated with some 'Lys-63'- specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex. SIMILARITY: Belongs to the peptidase M67A family. CSN5 subfamily. SIMILARITY: Contains 1 MPN (JAB/Mov34) domain. SEQUENCE CAUTION: Sequence=AAL82571.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92905
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000338 protein deneddylation GO:0000715 nucleotide-excision repair, DNA damage recognition GO:0006283 transcription-coupled nucleotide-excision repair GO:0006366 transcription from RNA polymerase II promoter GO:0006412 translation GO:0006413 translational initiation GO:0006508 proteolysis GO:0016579 protein deubiquitination GO:0043066 negative regulation of apoptotic process GO:0043687 post-translational protein modification GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046328 regulation of JNK cascade GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051726 regulation of cell cycle GO:1903894 regulation of IRE1-mediated unfolded protein response GO:1990182 exosomal secretion
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