Description: Homo sapiens mitochondrial ribosomal protein S9 (MRPS9), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_182640): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:105,654,483-105,716,418 Size: 61,936 Total Exon Count: 11 Strand: + Coding Region Position: hg19 chr2:105,654,551-105,716,219 Size: 61,669 Coding Exon Count: 11
ID:RT09_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S9, mitochondrial; Short=MRP-S9; Short=S9mt; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). INTERACTION: P04618:rev (xeno); NbExp=2; IntAct=EBI-721385, EBI-6164309; SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the ribosomal protein S9P family.
Diabetes Mellitus, Type 2 Jukka T Salonen et al. American journal of human genetics 2007, Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium., American journal of human genetics.
[PubMed 17668382]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 54211 - Ribosomal protein S5 domain 2-like
ModBase Predicted Comparative 3D Structure on P82933
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.