ID:MYH15_HUMAN DESCRIPTION: RecName: Full=Myosin-15; AltName: Full=Myosin heavy chain 15; FUNCTION: Muscle contraction (By similarity). SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity). SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils. DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity). SIMILARITY: Contains 1 IQ domain. SIMILARITY: Contains 1 myosin head-like domain. CAUTION: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15). SEQUENCE CAUTION: Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MYH15 CDC HuGE Published Literature: MYH15 Positive Disease Associations: Anticoagulants
, Body Composition Related Studies:
Anticoagulants Tiphaine Oudot-Mellakh et al. British journal of haematology 2012, Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project., British journal of haematology.
[PubMed 22443383]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y2K3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
