Human Gene PUSL1 (uc001aed.3)
Description: Homo sapiens pseudouridylate synthase-like 1 (PUSL1), mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:1,243,994-1,247,057 Size: 3,064 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr1:1,244,024-1,246,759 Size: 2,736 Coding Exon Count: 8
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PUSL1_HUMAN
DESCRIPTION: RecName: Full=tRNA pseudouridine synthase-like 1; EC=5.4.99.-; AltName: Full=tRNA pseudouridylate synthase-like 1; AltName: Full=tRNA-uridine isomerase-like 1;
CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR020103 - PsdUridine_synth_cat_dom
IPR001406 - PsdUridine_synth_TruA
IPR020097 - PsdUridine_synth_TruA_a/b_dom
IPR020095 - PsdUridine_synth_TruA_C
IPR020094 - PsdUridine_synth_TruA_N
Pfam Domains: PF01416 - tRNA pseudouridine synthase
SCOP Domains: 55120 - Pseudouridine synthase
ModBase Predicted Comparative 3D Structure on Q8N0Z8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF206758 - JP 2014500723-A/14261: Polycomb-Associated Non-Coding RNAs.AK075292 - Homo sapiens cDNA FLJ90811 fis, clone Y79AA1000888, weakly similar to TRNA PSEUDOURIDINE SYNTHASE A (EC 4.2.1.70).BC034304 - Homo sapiens pseudouridylate synthase-like 1, mRNA (cDNA clone MGC:30098 IMAGE:4778177), complete cds.HQ447403 - Synthetic construct Homo sapiens clone IMAGE:100070725; CCSB008176_02 pseudouridylate synthase-like 1 (PUSL1) gene, encodes complete protein.KJ900108 - Synthetic construct Homo sapiens clone ccsbBroadEn_09502 PUSL1 gene, encodes complete protein.AK298218 - Homo sapiens cDNA FLJ57412 complete cds, highly similar to tRNA pseudouridine synthase-like 1 (EC 5.4.99.-).AK027721 - Homo sapiens cDNA FLJ14815 fis, clone OVARC1000017.LF357557 - JP 2014500723-A/165060: Polycomb-Associated Non-Coding RNAs.JD107088 - Sequence 88112 from Patent EP1572962.JD486920 - Sequence 467944 from Patent EP1572962.JD424536 - Sequence 405560 from Patent EP1572962.JD185632 - Sequence 166656 from Patent EP1572962.LF383939 - JP 2014500723-A/191442: Polycomb-Associated Non-Coding RNAs.JD410504 - Sequence 391528 from Patent EP1572962.MA619516 - JP 2018138019-A/191442: Polycomb-Associated Non-Coding RNAs.MA442335 - JP 2018138019-A/14261: Polycomb-Associated Non-Coding RNAs.MA593134 - JP 2018138019-A/165060: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: B4DP76, NM_153339, NP_699170, PUSL1_HUMAN, Q5TA41, Q8N0Z8UCSC ID: uc001aed.3RefSeq Accession: NM_153339
Protein: Q8N0Z8
(aka PUSL1_HUMAN or PUL1_HUMAN)
CCDS: CCDS20.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_153339.1
exon count:
8 CDS single in 3' UTR:
no
RNA size:
1262
ORF size:
912 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
1606.00 frame shift in genome:
no
% Coverage:
98.26
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.