Description: Homo sapiens cytochrome c oxidase subunit VIIb (COX7B), nuclear gene encoding mitochondrial protein, mRNA. RefSeq Summary (NM_001866): Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chrX:77,154,961-77,160,881 Size: 5,921 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chrX:77,155,051-77,160,758 Size: 5,708 Coding Exon Count: 3
ID:COX7B_HUMAN DESCRIPTION: RecName: Full=Cytochrome c oxidase subunit 7B, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIb; Flags: Precursor; FUNCTION: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity). SIMILARITY: Belongs to the cytochrome c oxidase VIIb family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05392 - Cytochrome C oxidase chain VIIB
SCOP Domains: 81423 - Mitochondrial cytochrome c oxidase subunit VIIb
ModBase Predicted Comparative 3D Structure on P24311
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P24311 (Reactome details) participates in the following event(s):
R-HSA-163214 Electron transfer from reduced cytochrome c to molecular oxygen R-HSA-611105 Respiratory electron transport R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-212436 Generic Transcription Pathway R-HSA-1430728 Metabolism R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
GeneReviews article(s) related to gene COX7B: cdh-ov (Congenital Diaphragmatic Hernia Overview) microph-lsd (Microphthalmia with Linear Skin Defects Syndrome)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001866.2
exon count:
3
CDS single in 3' UTR:
no
RNA size:
456
ORF size:
243
CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
686.00
frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0
# strange splices:
0
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Methods, Credits, and Use Restrictions
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