Human Gene INHBE (uc001snw.3) Description and Page Index
  Description: Homo sapiens inhibin, beta E (INHBE), mRNA.
RefSeq Summary (NM_031479): This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA046954.1, BC005161.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000266646.3/ ENSP00000266646.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr12:57,849,096-57,851,791 Size: 2,696 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr12:57,849,320-57,850,631 Size: 1,312 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:57,849,096-57,851,791)mRNA (may differ from genome)Protein (350 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: INHBE_HUMAN
DESCRIPTION: RecName: Full=Inhibin beta E chain; AltName: Full=Activin beta-E chain; Flags: Precursor;
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
SUBUNIT: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the TGF-beta family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): INHBE
CDC HuGE Published Literature: INHBE

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.50 RPKM in Liver
Total median expression: 51.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.40224-0.350 Picture PostScript Text
3' UTR -417.641160-0.360 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001318 - Inhibin_betaC
IPR001839 - TGF-b_C
IPR001111 - TGF-b_N
IPR015615 - TGF-beta-rel
IPR017948 - TGFb_CS

Pfam Domains:
PF00019 - Transforming growth factor beta like domain

SCOP Domains:
57501 - Cystine-knot cytokines

ModBase Predicted Comparative 3D Structure on P58166
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005179 hormone activity
GO:0008083 growth factor activity

Biological Process:
GO:0010469 regulation of receptor activity
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042981 regulation of apoptotic process
GO:0043408 regulation of MAPK cascade
GO:0048468 cell development
GO:0060395 SMAD protein signal transduction

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  AK308647 - Homo sapiens cDNA, FLJ98688.
AK075285 - Homo sapiens cDNA FLJ90804 fis, clone Y79AA1000426, highly similar to Inhibin beta E chain precursor.
BC005161 - Homo sapiens inhibin, beta E, mRNA (cDNA clone MGC:4638 IMAGE:3529092), complete cds.
AF412024 - Homo sapiens activin beta E subunit mRNA, complete cds.
JD279309 - Sequence 260333 from Patent EP1572962.
JD492345 - Sequence 473369 from Patent EP1572962.
JD148582 - Sequence 129606 from Patent EP1572962.
JD343789 - Sequence 324813 from Patent EP1572962.
JF432681 - Synthetic construct Homo sapiens clone IMAGE:100073919 inhibin, beta E (INHBE) gene, encodes complete protein.
KJ894898 - Synthetic construct Homo sapiens clone ccsbBroadEn_04292 INHBE gene, encodes complete protein.
EU831419 - Synthetic construct Homo sapiens clone HAIB:100066448; DKFZo008B0617 inhibin, beta E protein (INHBE) gene, encodes complete protein.
EU831512 - Synthetic construct Homo sapiens clone HAIB:100066541; DKFZo004B0618 inhibin, beta E protein (INHBE) gene, encodes complete protein.
CQ873708 - Sequence 127 from Patent WO2004076622.
DD413545 - Regulation of Mammalian Cells.
JD195107 - Sequence 176131 from Patent EP1572962.
JD196896 - Sequence 177920 from Patent EP1572962.
JD475544 - Sequence 456568 from Patent EP1572962.
JD049336 - Sequence 30360 from Patent EP1572962.
JD548301 - Sequence 529325 from Patent EP1572962.
JD045695 - Sequence 26719 from Patent EP1572962.
JD343010 - Sequence 324034 from Patent EP1572962.
JD323862 - Sequence 304886 from Patent EP1572962.
JD521220 - Sequence 502244 from Patent EP1572962.
JD309638 - Sequence 290662 from Patent EP1572962.
JD309748 - Sequence 290772 from Patent EP1572962.
JD068772 - Sequence 49796 from Patent EP1572962.
JD276130 - Sequence 257154 from Patent EP1572962.
JD428997 - Sequence 410021 from Patent EP1572962.
JD445465 - Sequence 426489 from Patent EP1572962.
JD058653 - Sequence 39677 from Patent EP1572962.
JD299978 - Sequence 281002 from Patent EP1572962.
JD541221 - Sequence 522245 from Patent EP1572962.
JD262078 - Sequence 243102 from Patent EP1572962.
JD165231 - Sequence 146255 from Patent EP1572962.
JD542919 - Sequence 523943 from Patent EP1572962.
JD213076 - Sequence 194100 from Patent EP1572962.
JD463108 - Sequence 444132 from Patent EP1572962.
JD413748 - Sequence 394772 from Patent EP1572962.
JD533846 - Sequence 514870 from Patent EP1572962.
JD185143 - Sequence 166167 from Patent EP1572962.
JD322001 - Sequence 303025 from Patent EP1572962.
JD322002 - Sequence 303026 from Patent EP1572962.
JD068502 - Sequence 49526 from Patent EP1572962.
JD552282 - Sequence 533306 from Patent EP1572962.
JD329656 - Sequence 310680 from Patent EP1572962.
JD488021 - Sequence 469045 from Patent EP1572962.
JD261721 - Sequence 242745 from Patent EP1572962.
JD264763 - Sequence 245787 from Patent EP1572962.
JD476928 - Sequence 457952 from Patent EP1572962.
JD311507 - Sequence 292531 from Patent EP1572962.
JD311508 - Sequence 292532 from Patent EP1572962.
JD112794 - Sequence 93818 from Patent EP1572962.
JD268235 - Sequence 249259 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04060 - Cytokine-cytokine receptor interaction
hsa04350 - TGF-beta signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: INHBE_HUMAN, NM_031479, NP_113667, P58166
UCSC ID: uc001snw.3
RefSeq Accession: NM_031479
Protein: P58166 (aka INHBE_HUMAN or IHBE_HUMAN)
CCDS: CCDS8939.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_031479.3
exon count: 2CDS single in 3' UTR: no RNA size: 2453
ORF size: 1053CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2257.00frame shift in genome: no % Coverage: 99.35
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.