Human Gene PPM1B (uc002rtt.3) Description and Page Index
Description: Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1B (PPM1B), transcript variant 1, mRNA. RefSeq Summary (NM_002706): The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:44,396,000-44,458,611 Size: 62,612 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr2:44,428,339-44,457,857 Size: 29,519 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75688
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006470 protein dephosphorylation GO:0006499 N-terminal protein myristoylation GO:0032688 negative regulation of interferon-beta production GO:0035970 peptidyl-threonine dephosphorylation GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0050687 negative regulation of defense response to virus GO:1901223 negative regulation of NIK/NF-kappaB signaling