Human Gene KLC2 (uc001ohb.2) Description and Page Index
Description: Homo sapiens kinesin light chain 2 (KLC2), transcript variant 1, mRNA. RefSeq Summary (NM_022822): The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016]. Transcript (Including UTRs) Position: hg19 chr11:66,025,174-66,035,332 Size: 10,159 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr11:66,026,066-66,034,427 Size: 8,362 Coding Exon Count: 15
ID:KLC2_HUMAN DESCRIPTION: RecName: Full=Kinesin light chain 2; Short=KLC 2; FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). SUBUNIT: Oligomeric complex composed of two heavy chains and two light chains (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). SIMILARITY: Belongs to the kinesin light chain family. SIMILARITY: Contains 6 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0B6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II