Description: Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 15 (NUDT15), mRNA. RefSeq Summary (NM_018283): This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]. Transcript (Including UTRs) Position: hg19 chr13:48,611,703-48,621,282 Size: 9,580 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr13:48,611,883-48,619,935 Size: 8,053 Coding Exon Count: 3
ID:NUD15_HUMAN DESCRIPTION: RecName: Full=Probable 8-oxo-dGTP diphosphatase NUDT15; Short=8-oxo-dGTPase NUDT15; EC=3.6.1.55; AltName: Full=7,8-dihydro-8-oxoguanine-triphosphatase NUDT15; AltName: Full=MutT homolog 2; Short=MTH2; AltName: Full=Nucleoside diphosphate-linked moiety X motif 15; Short=Nudix motif 15; FUNCTION: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. CATALYTIC ACTIVITY: 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. COFACTOR: Magnesium or manganese. Magnesium may be the real cofactor in vivo (By similarity). SUBUNIT: Interacts with PCNA; interaction is disrupted in response to UV irradiation. SIMILARITY: Belongs to the Nudix hydrolase family. SIMILARITY: Contains 1 nudix hydrolase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NV35
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000278 mitotic cell cycle GO:0006195 purine nucleotide catabolic process GO:0006203 dGTP catabolic process GO:0034656 nucleobase-containing small molecule catabolic process GO:0042262 DNA protection GO:0042738 exogenous drug catabolic process GO:0061136 regulation of proteasomal protein catabolic process GO:1901292 nucleoside phosphate catabolic process
US Server
