Human Gene PRAMEF10 (uc001auo.3)
Description: Homo sapiens PRAME family member 10 (PRAMEF10), mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:12,952,727-12,958,094 Size: 5,368 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr1:12,952,747-12,955,678 Size: 2,932 Coding Exon Count: 3
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PRA10_HUMAN
DESCRIPTION: RecName: Full=PRAME family member 10;
SIMILARITY: Belongs to the PRAME family.SIMILARITY: Contains 2 LRR (leucine-rich) repeats.SEQUENCE CAUTION: Sequence=CAA17876.1; Type=Erroneous gene model prediction;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR026292 - PRAME/Leu_rich_rep-con_p14
IPR026271 - PRAME_family
SCOP Domains: 52047 - RNI-like
ModBase Predicted Comparative 3D Structure on O60809
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0008284 positive regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Descriptions from all associated GenBank mRNAs
BC112208 - Homo sapiens PRAME family member 10, mRNA (cDNA clone MGC:138413 IMAGE:8327676), complete cds.BC112210 - Homo sapiens PRAME family member 10, mRNA (cDNA clone MGC:138415 IMAGE:8327678), complete cds.KJ900650 - Synthetic construct Homo sapiens clone ccsbBroadEn_10044 PRAMEF10 gene, encodes complete protein.AL049682 - Human gene from PAC 845O24, chromosome 1, similar to preferentially expressed antigen of melanoma.JD079199 - Sequence 60223 from Patent EP1572962.JD241891 - Sequence 222915 from Patent EP1572962.JD193893 - Sequence 174917 from Patent EP1572962.JD399778 - Sequence 380802 from Patent EP1572962.JD227087 - Sequence 208111 from Patent EP1572962.JD307962 - Sequence 288986 from Patent EP1572962.JD124352 - Sequence 105376 from Patent EP1572962.JD539770 - Sequence 520794 from Patent EP1572962.JD143589 - Sequence 124613 from Patent EP1572962.JD143588 - Sequence 124612 from Patent EP1572962.JD165569 - Sequence 146593 from Patent EP1572962.JD036562 - Sequence 17586 from Patent EP1572962.JD555642 - Sequence 536666 from Patent EP1572962.JD539988 - Sequence 521012 from Patent EP1572962.JD432113 - Sequence 413137 from Patent EP1572962.JD265566 - Sequence 246590 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: NM_001039361, NP_001034450, O60809, PRA10_HUMAN, Q2M1V2UCSC ID: uc001auo.3RefSeq Accession: NM_001039361
Protein: O60809
(aka PRA10_HUMAN)
CCDS: CCDS41255.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001039361.3
exon count:
4 CDS single in 3' UTR:
no
RNA size:
1518
ORF size:
1425 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2932.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.