Human Gene DNAJC7 (uc002hyo.3) Description and Page Index
  Description: Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7), transcript variant 1, mRNA.
RefSeq Summary (NM_003315): This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
Transcript (Including UTRs)
   Position: hg19 chr17:40,128,439-40,169,715 Size: 41,277 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr17:40,128,751-40,169,434 Size: 40,684 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:40,128,439-40,169,715)mRNA (may differ from genome)Protein (494 aa)
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OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DNJC7_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 7; AltName: Full=Tetratricopeptide repeat protein 2; Short=TPR repeat protein 2;
FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
SUBUNIT: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1. Interacts with NR1I3. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with HSPA8.
INTERACTION: P12504:vif (xeno); NbExp=3; IntAct=EBI-357552, EBI-779991;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules (By similarity).
SIMILARITY: Contains 1 J domain.
SIMILARITY: Contains 9 TPR repeats.
SEQUENCE CAUTION: Sequence=AAB36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH33772.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.77 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 1145.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -132.70281-0.472 Picture PostScript Text
3' UTR -97.90312-0.314 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR023114 - Elongated_TPR_rpt_dom
IPR003095 - Hsp_DnaJ
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF00226 - DnaJ domain
PF07719 - Tetratricopeptide repeat
PF08238 - Sel1 repeat
PF13174 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13414 - TPR repeat
PF13431 - Tetratricopeptide repeat
PF13432 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
46565 - Chaperone J-domain

ModBase Predicted Comparative 3D Structure on Q99615
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsemblFlyBase  
 Protein SequenceProtein SequenceProtein Sequence  
 AlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0031072 heat shock protein binding

Biological Process:
GO:0006457 protein folding
GO:0032781 positive regulation of ATPase activity
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:1900034 regulation of cellular response to heat

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF384801 - JP 2014500723-A/192304: Polycomb-Associated Non-Coding RNAs.
BC003601 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:911 IMAGE:3543074), complete cds.
BX647209 - Homo sapiens mRNA; cDNA DKFZp686I18256 (from clone DKFZp686I18256).
BC011837 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:20075 IMAGE:3945721), complete cds.
AB209834 - Homo sapiens mRNA for DnaJ (Hsp40) homolog, subfamily C, member 7 variant protein.
U46571 - Human tetratricopeptide repeat protein (tpr2) mRNA, complete cds.
AK291047 - Homo sapiens cDNA FLJ76281 complete cds, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7), mRNA.
BC033772 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:45296 IMAGE:3924081), complete cds.
AK298860 - Homo sapiens cDNA FLJ51941 complete cds, highly similar to DnaJ homolog subfamily C member 7.
JD472149 - Sequence 453173 from Patent EP1572962.
JD484125 - Sequence 465149 from Patent EP1572962.
JD077160 - Sequence 58184 from Patent EP1572962.
LF327796 - JP 2014500723-A/135299: Polycomb-Associated Non-Coding RNAs.
JD329473 - Sequence 310497 from Patent EP1572962.
AK296602 - Homo sapiens cDNA FLJ54791 complete cds, highly similar to DnaJ homolog subfamily C member 7.
JD429390 - Sequence 410414 from Patent EP1572962.
JD202697 - Sequence 183721 from Patent EP1572962.
AK316081 - Homo sapiens cDNA, FLJ78980 complete cds, highly similar to DnaJ homolog subfamily C member 7.
JD040791 - Sequence 21815 from Patent EP1572962.
LF327797 - JP 2014500723-A/135300: Polycomb-Associated Non-Coding RNAs.
KJ892328 - Synthetic construct Homo sapiens clone ccsbBroadEn_01722 DNAJC7 gene, encodes complete protein.
DQ893064 - Synthetic construct clone IMAGE:100005694; FLH193230.01X; RZPDo839E0178D DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene, encodes complete protein.
KJ901813 - Synthetic construct Homo sapiens clone ccsbBroadEn_11207 DNAJC7 gene, encodes complete protein.
KJ892327 - Synthetic construct Homo sapiens clone ccsbBroadEn_01721 DNAJC7 gene, encodes complete protein.
DQ896317 - Synthetic construct Homo sapiens clone IMAGE:100010777; FLH193226.01L; RZPDo839E0168D DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene, encodes complete protein.
AB587519 - Synthetic construct DNA, clone: pF1KE0031, Homo sapiens DNAJC7 gene for DnaJ (Hsp40) homolog, subfamily C, member 7, without stop codon, in Flexi system.
AM393511 - Synthetic construct Homo sapiens clone IMAGE:100002500 for hypothetical protein (DNAJC7 gene).
LF327799 - JP 2014500723-A/135302: Polycomb-Associated Non-Coding RNAs.
LF327800 - JP 2014500723-A/135303: Polycomb-Associated Non-Coding RNAs.
LF327801 - JP 2014500723-A/135304: Polycomb-Associated Non-Coding RNAs.
CU678526 - Synthetic construct Homo sapiens gateway clone IMAGE:100022474 5' read DNAJC7 mRNA.
LF327802 - JP 2014500723-A/135305: Polycomb-Associated Non-Coding RNAs.
AK308016 - Homo sapiens cDNA, FLJ97964.
LF327803 - JP 2014500723-A/135306: Polycomb-Associated Non-Coding RNAs.
LF327804 - JP 2014500723-A/135307: Polycomb-Associated Non-Coding RNAs.
CU680076 - Synthetic construct Homo sapiens gateway clone IMAGE:100019667 5' read DNAJC7 mRNA.
CU689734 - Synthetic construct Homo sapiens gateway clone IMAGE:100019617 5' read DNAJC7 mRNA.
JD022912 - Sequence 3936 from Patent EP1572962.
JD027821 - Sequence 8845 from Patent EP1572962.
LF327809 - JP 2014500723-A/135312: Polycomb-Associated Non-Coding RNAs.
LF327816 - JP 2014500723-A/135319: Polycomb-Associated Non-Coding RNAs.
MA620378 - JP 2018138019-A/192304: Polycomb-Associated Non-Coding RNAs.
MA563373 - JP 2018138019-A/135299: Polycomb-Associated Non-Coding RNAs.
MA563374 - JP 2018138019-A/135300: Polycomb-Associated Non-Coding RNAs.
MA563376 - JP 2018138019-A/135302: Polycomb-Associated Non-Coding RNAs.
MA563377 - JP 2018138019-A/135303: Polycomb-Associated Non-Coding RNAs.
MA563378 - JP 2018138019-A/135304: Polycomb-Associated Non-Coding RNAs.
MA563379 - JP 2018138019-A/135305: Polycomb-Associated Non-Coding RNAs.
MA563380 - JP 2018138019-A/135306: Polycomb-Associated Non-Coding RNAs.
MA563381 - JP 2018138019-A/135307: Polycomb-Associated Non-Coding RNAs.
MA563386 - JP 2018138019-A/135312: Polycomb-Associated Non-Coding RNAs.
MA563393 - JP 2018138019-A/135319: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99615 (Reactome details) participates in the following event(s):

R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: DNJC7_HUMAN, NM_003315, NP_001138238, Q7Z784, Q99615, TPR2, TTC2
UCSC ID: uc002hyo.3
RefSeq Accession: NM_003315
Protein: Q99615 (aka DNJC7_HUMAN or DJC7_HUMAN)
CCDS: CCDS45677.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_003315.3
exon count: 14CDS single in 3' UTR: no RNA size: 2096
ORF size: 1485CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3137.50frame shift in genome: no % Coverage: 99.14
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.