Human Gene ZNF664 (uc001uga.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 664 (ZNF664), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:124,457,762-124,499,986 Size: 42,225 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr12:124,496,692-124,497,477 Size: 786 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:124,457,762-124,499,986)mRNA (may differ from genome)Protein (261 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZN664_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 664; AltName: Full=Zinc finger protein 176; AltName: Full=Zinc finger protein from organ of Corti;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 9 C2H2-type zinc fingers.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF664
CDC HuGE Published Literature: ZNF664
Positive Disease Associations: Body Height , Cholesterol, HDL , Depressive Disorder, Major , Myocardial Infarction , Triglycerides
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Cholesterol, HDL
    Tanya M Teslovich et al. Nature 2010, Biological, clinical and population relevance of 95 loci for blood lipids., Nature. [PubMed 20686565]
  3. Depressive Disorder, Major
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF664
Diseases sorted by gene-association score: deafness, autosomal dominant 41 (13), deafness, autosomal dominant 25 (12), clubfoot (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 65.19 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 1285.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -349.94977-0.358 Picture PostScript Text
3' UTR -715.672509-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q8N3J9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AL834266 - Homo sapiens mRNA; cDNA DKFZp761B128 (from clone DKFZp761B128).
BC051696 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:51237 IMAGE:5276234), complete cds.
JD223550 - Sequence 204574 from Patent EP1572962.
BC037793 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone IMAGE:4793237).
JD134222 - Sequence 115246 from Patent EP1572962.
BX647762 - Homo sapiens mRNA; cDNA DKFZp686M1851 (from clone DKFZp686M1851).
AK056034 - Homo sapiens cDNA FLJ31472 fis, clone NT2NE2001442, highly similar to Homo sapiens zinc finger protein 664 (ZNF664), mRNA.
JD394813 - Sequence 375837 from Patent EP1572962.
JD390665 - Sequence 371689 from Patent EP1572962.
JD404065 - Sequence 385089 from Patent EP1572962.
JD248681 - Sequence 229705 from Patent EP1572962.
JD371112 - Sequence 352136 from Patent EP1572962.
JD498486 - Sequence 479510 from Patent EP1572962.
JD216766 - Sequence 197790 from Patent EP1572962.
JD399757 - Sequence 380781 from Patent EP1572962.
JD455848 - Sequence 436872 from Patent EP1572962.
JD391688 - Sequence 372712 from Patent EP1572962.
JD420617 - Sequence 401641 from Patent EP1572962.
JD280268 - Sequence 261292 from Patent EP1572962.
JD311449 - Sequence 292473 from Patent EP1572962.
BC017960 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:24083 IMAGE:4608465), complete cds.
JD434697 - Sequence 415721 from Patent EP1572962.
BC093848 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:120883 IMAGE:7939693), complete cds.
BC101530 - Homo sapiens zinc finger protein 664, mRNA (cDNA clone MGC:126579 IMAGE:8069036), complete cds.
AB463374 - Synthetic construct DNA, clone: pF1KB8406, Homo sapiens ZNF664 gene for zinc finger protein 664, without stop codon, in Flexi system.
AM392806 - Synthetic construct Homo sapiens clone IMAGE:100001761 for hypothetical protein (ZNF664 gene).
EU446574 - Synthetic construct Homo sapiens clone IMAGE:100070181; IMAGE:100011783; FLH257305.01L zinc finger protein 664 (ZNF664) gene, encodes complete protein.
L41669 - Homo sapiens ZFOC1 mRNA, partial cds.
BC004339 - Homo sapiens cDNA clone IMAGE:3631961, **** WARNING: chimeric clone ****.
AF024695 - Homo sapiens clone L3-14 zinc finger protein mRNA, partial cds.
AK023009 - Homo sapiens cDNA FLJ12947 fis, clone NT2RP2005287.
JD203392 - Sequence 184416 from Patent EP1572962.
JD395020 - Sequence 376044 from Patent EP1572962.
JD302247 - Sequence 283271 from Patent EP1572962.
JD532901 - Sequence 513925 from Patent EP1572962.
JD444217 - Sequence 425241 from Patent EP1572962.
JD553523 - Sequence 534547 from Patent EP1572962.
JD250549 - Sequence 231573 from Patent EP1572962.
JD266328 - Sequence 247352 from Patent EP1572962.
JD221332 - Sequence 202356 from Patent EP1572962.
JD268242 - Sequence 249266 from Patent EP1572962.
JD047457 - Sequence 28481 from Patent EP1572962.
JD242400 - Sequence 223424 from Patent EP1572962.
JD471312 - Sequence 452336 from Patent EP1572962.
JD520438 - Sequence 501462 from Patent EP1572962.
JD207496 - Sequence 188520 from Patent EP1572962.
JD140906 - Sequence 121930 from Patent EP1572962.
JD469178 - Sequence 450202 from Patent EP1572962.
JD091107 - Sequence 72131 from Patent EP1572962.
JD225791 - Sequence 206815 from Patent EP1572962.
JD037266 - Sequence 18290 from Patent EP1572962.
JD359221 - Sequence 340245 from Patent EP1572962.
JD076953 - Sequence 57977 from Patent EP1572962.
JD367366 - Sequence 348390 from Patent EP1572962.
JD208193 - Sequence 189217 from Patent EP1572962.
JD299619 - Sequence 280643 from Patent EP1572962.
JD328157 - Sequence 309181 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N3J9 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: B3KP97, NM_001204298, NP_689650, Q15914, Q3ZCQ7, Q8N3J9, ZFOC1, ZN664_HUMAN, ZNF196
UCSC ID: uc001uga.3
RefSeq Accession: NM_001204298
Protein: Q8N3J9 (aka ZN664_HUMAN)
CCDS: CCDS9257.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001204298.1
exon count: 5CDS single in 3' UTR: no RNA size: 4289
ORF size: 786CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1380.50frame shift in genome: no % Coverage: 99.60
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.