Human Gene ZNF583 (uc010ygl.1) Description and Page Index
  Description: Homo sapiens zinc finger protein 583 (ZNF583), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:56,915,383-56,936,400 Size: 21,018 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:56,918,484-56,935,737 Size: 17,254 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:56,915,383-56,936,400)mRNA (may differ from genome)Protein (569 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCHPRDLynxMGIneXtProtPubMed
ReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN583_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 583; AltName: Full=Zinc finger protein L3-5;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 12 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.09 RPKM in Testis
Total median expression: 37.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.10165-0.382 Picture PostScript Text
3' UTR -131.84663-0.199 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q96ND8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK055592 - Homo sapiens cDNA FLJ31030 fis, clone HSYRA1000137, moderately similar to ZINC FINGER PROTEIN 184.
BC111772 - Homo sapiens zinc finger protein 583, mRNA (cDNA clone MGC:133237 IMAGE:40034375), complete cds.
AB464406 - Synthetic construct DNA, clone: pF1KB8154, Homo sapiens ZNF583 gene for zinc finger protein 583, without stop codon, in Flexi system.
EU446580 - Synthetic construct Homo sapiens clone IMAGE:100069923; IMAGE:100011789; FLH257149.01L zinc finger protein 583 (ZNF583) gene, encodes complete protein.
KJ895612 - Synthetic construct Homo sapiens clone ccsbBroadEn_05006 ZNF583 gene, encodes complete protein.
AL833236 - Homo sapiens mRNA; cDNA DKFZp761G2219 (from clone DKFZp761G2219).
AF024698 - Homo sapiens clone L3-5 zinc finger protein mRNA, partial cds.
JD314870 - Sequence 295894 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD322343 - Sequence 303367 from Patent EP1572962.
JD251791 - Sequence 232815 from Patent EP1572962.
JD139209 - Sequence 120233 from Patent EP1572962.
JD304677 - Sequence 285701 from Patent EP1572962.
JD399620 - Sequence 380644 from Patent EP1572962.
JD491044 - Sequence 472068 from Patent EP1572962.
JD279948 - Sequence 260972 from Patent EP1572962.
JD268256 - Sequence 249280 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96ND8 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001159860, NP_689691, O14850, Q2NKK3, Q96ND8, ZN583_HUMAN
UCSC ID: uc010ygl.1
RefSeq Accession: NM_001159860
Protein: Q96ND8 (aka ZN583_HUMAN)
CCDS: CCDS12943.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001159860.1
exon count: 5CDS single in 3' UTR: no RNA size: 2538
ORF size: 1710CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3620.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
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