Human Gene TRIML1 (uc003izm.1) Description and Page Index
  Description: Homo sapiens tripartite motif family-like 1 (TRIML1), mRNA.
RefSeq Summary (NM_178556): The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]. ##Evidence-Data-START## Transcript exon combination :: AK093499.1, BC113860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332517.4/ ENSP00000327738.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr4:189,060,598-189,068,649 Size: 8,052 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr4:189,060,713-189,068,526 Size: 7,814 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:189,060,598-189,068,649)mRNA (may differ from genome)Protein (468 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Probable E3 ubiquitin-protein ligase TRIML1; EC=6.3.2.-; AltName: Full=RING finger protein 209; AltName: Full=Tripartite motif family-like protein 1;
FUNCTION: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By similarity).
PATHWAY: Protein modification; protein ubiquitination.
SUBUNIT: Interacts with USP5 (By similarity).
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 RING-type zinc finger.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.33 RPKM in Testis
Total median expression: 13.33 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.30115-0.229 Picture PostScript Text
3' UTR -30.40123-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR008985 - ConA-like_lec_gl_sf
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt
IPR001841 - Znf_RING
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00622 - SPRY domain
PF13445 - RING-type zinc-finger
PF13765 - SPRY-associated domain
PF13923 - Zinc finger, C3HC4 type (RING finger)
PF15227 - zinc finger of C3HC4-type, RING

SCOP Domains:
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q8N9V2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016740 transferase activity
GO:0046872 metal ion binding

Biological Process:
GO:0007275 multicellular organism development
GO:0016567 protein ubiquitination

-  Descriptions from all associated GenBank mRNAs
  AK093499 - Homo sapiens cDNA FLJ36180 fis, clone TESTI2026605, weakly similar to 52 KDA RO PROTEIN.
AX748169 - Sequence 1694 from Patent EP1308459.
LF384364 - JP 2014500723-A/191867: Polycomb-Associated Non-Coding RNAs.
BC113860 - Homo sapiens tripartite motif family-like 1, mRNA (cDNA clone MGC:138639 IMAGE:40033174), complete cds.
BC114469 - Homo sapiens tripartite motif family-like 1, mRNA (cDNA clone MGC:138638 IMAGE:40033173), complete cds.
JD280019 - Sequence 261043 from Patent EP1572962.
JD401338 - Sequence 382362 from Patent EP1572962.
JD070646 - Sequence 51670 from Patent EP1572962.
LF372253 - JP 2014500723-A/179756: Polycomb-Associated Non-Coding RNAs.
LF372252 - JP 2014500723-A/179755: Polycomb-Associated Non-Coding RNAs.
LF372248 - JP 2014500723-A/179751: Polycomb-Associated Non-Coding RNAs.
BC015684 - Homo sapiens tripartite motif family-like 1, mRNA (cDNA clone IMAGE:4650977), complete cds.
KJ905083 - Synthetic construct Homo sapiens clone ccsbBroadEn_14477 TRIML1 gene, encodes complete protein.
CU677391 - Synthetic construct Homo sapiens gateway clone IMAGE:100017562 5' read TRIML1 mRNA.
LF372239 - JP 2014500723-A/179742: Polycomb-Associated Non-Coding RNAs.
LF372238 - JP 2014500723-A/179741: Polycomb-Associated Non-Coding RNAs.
LF372235 - JP 2014500723-A/179738: Polycomb-Associated Non-Coding RNAs.
JD261191 - Sequence 242215 from Patent EP1572962.
LF372233 - JP 2014500723-A/179736: Polycomb-Associated Non-Coding RNAs.
MA619941 - JP 2018138019-A/191867: Polycomb-Associated Non-Coding RNAs.
MA607830 - JP 2018138019-A/179756: Polycomb-Associated Non-Coding RNAs.
MA607829 - JP 2018138019-A/179755: Polycomb-Associated Non-Coding RNAs.
MA607825 - JP 2018138019-A/179751: Polycomb-Associated Non-Coding RNAs.
MA607816 - JP 2018138019-A/179742: Polycomb-Associated Non-Coding RNAs.
MA607815 - JP 2018138019-A/179741: Polycomb-Associated Non-Coding RNAs.
MA607812 - JP 2018138019-A/179738: Polycomb-Associated Non-Coding RNAs.
MA607810 - JP 2018138019-A/179736: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_178556, NP_848651, Q8N9V2, Q96BE5, RNF209, TRIML_HUMAN
UCSC ID: uc003izm.1
RefSeq Accession: NM_178556
Protein: Q8N9V2 (aka TRIML_HUMAN)
CCDS: CCDS3851.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_178556.3
exon count: 6CDS single in 3' UTR: no RNA size: 1645
ORF size: 1407CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3014.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.