Human Gene TRIML1 (uc003izm.1) Description and Page Index
Description: Homo sapiens tripartite motif family-like 1 (TRIML1), mRNA. RefSeq Summary (NM_178556): The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]. ##Evidence-Data-START## Transcript exon combination :: AK093499.1, BC113860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000332517.4/ ENSP00000327738.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr4:189,060,598-189,068,649 Size: 8,052 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr4:189,060,713-189,068,526 Size: 7,814 Coding Exon Count: 6
ID:TRIML_HUMAN DESCRIPTION: RecName: Full=Probable E3 ubiquitin-protein ligase TRIML1; EC=6.3.2.-; AltName: Full=RING finger protein 209; AltName: Full=Tripartite motif family-like protein 1; FUNCTION: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with USP5 (By similarity). SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N9V2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.