Human Gene ZNF585B (uc002ofq.3)
  Description: Homo sapiens zinc finger protein 585B (ZNF585B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:37,672,481-37,701,451 Size: 28,971 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr19:37,676,129-37,698,013 Size: 21,885 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:37,672,481-37,701,451)mRNA (may differ from genome)Protein (769 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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H-INVHGNCHPRDLynxMGIneXtProt
PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Z585B_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 585B; AltName: Full=zinc finger protein 41-like protein;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 21 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAB55400.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF585B
CDC HuGE Published Literature: ZNF585B
Positive Disease Associations: Asthma
Related Studies:
  1. Asthma
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.89 RPKM in Pituitary
Total median expression: 149.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.50252-0.371 Picture PostScript Text
3' UTR -990.403648-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q52M93
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK098695 - Homo sapiens cDNA FLJ25829 fis, clone TST08126.
AK090574 - Homo sapiens cDNA FLJ33255 fis, clone ASTRO2005553.
AX746517 - Sequence 42 from Patent EP1308459.
BC029737 - Homo sapiens zinc finger protein 585B, mRNA (cDNA clone IMAGE:3864509), partial cds.
AK094989 - Homo sapiens cDNA FLJ37670 fis, clone BRHIP2011933, highly similar to Zinc finger protein 585B.
AY147015 - Homo sapiens zinc finger protein 41-like protein mRNA, complete cds.
AK027834 - Homo sapiens cDNA FLJ14928 fis, clone PLACE1009099, moderately similar to ZINC FINGER PROTEIN 41.
AK091586 - Homo sapiens cDNA FLJ34267 fis, clone FEBRA2002707, highly similar to Zinc finger protein 585B.
AX747075 - Sequence 600 from Patent EP1308459.
JD188629 - Sequence 169653 from Patent EP1572962.
JD084043 - Sequence 65067 from Patent EP1572962.
JD163901 - Sequence 144925 from Patent EP1572962.
JD290911 - Sequence 271935 from Patent EP1572962.
JD097364 - Sequence 78388 from Patent EP1572962.
BC093625 - Homo sapiens zinc finger protein 585B, mRNA (cDNA clone MGC:120660 IMAGE:7939470), complete cds.
EU446556 - Synthetic construct Homo sapiens clone IMAGE:100069942; IMAGE:100011765; FLH257105.01L zinc finger protein 585B (ZNF585B) gene, encodes complete protein.
BC051277 - Homo sapiens zinc finger protein 585B, mRNA (cDNA clone IMAGE:6250801), containing frame-shift errors.
BC067088 - Homo sapiens zinc finger protein 585B, mRNA (cDNA clone IMAGE:6208925), partial cds.
BC080550 - Homo sapiens zinc finger protein 585B, mRNA (cDNA clone IMAGE:6249350).
JD084020 - Sequence 65044 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
AF024705 - Homo sapiens clone L4-10 zinc finger protein mRNA, partial cds.
JD314882 - Sequence 295906 from Patent EP1572962.
JD507138 - Sequence 488162 from Patent EP1572962.
JD314870 - Sequence 295894 from Patent EP1572962.
JD314878 - Sequence 295902 from Patent EP1572962.
JD314877 - Sequence 295901 from Patent EP1572962.
JD314879 - Sequence 295903 from Patent EP1572962.
JD434463 - Sequence 415487 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD314816 - Sequence 295840 from Patent EP1572962.
JD109341 - Sequence 90365 from Patent EP1572962.
JD489776 - Sequence 470800 from Patent EP1572962.
JD216322 - Sequence 197346 from Patent EP1572962.
JD170893 - Sequence 151917 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q52M93 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_152279, NP_689492, Q52M93, Q8IZD3, Q96JW6, Z585B_HUMAN
UCSC ID: uc002ofq.3
RefSeq Accession: NM_152279
Protein: Q52M93 (aka Z585B_HUMAN)
CCDS: CCDS12500.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152279.3
exon count: 5CDS single in 3' UTR: no RNA size: 6210
ORF size: 2310CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4752.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 5520# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.