Description: Homo sapiens Rho GTPase activating protein 21 (ARHGAP21), mRNA. RefSeq Summary (NM_020824): ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr10:24,872,538-25,012,597 Size: 140,060 Total Exon Count: 26 Strand: - Coding Region Position: hg19 chr10:24,873,341-25,010,828 Size: 137,488 Coding Exon Count: 25
ID:RHG21_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 21; AltName: Full=Rho GTPase-activating protein 10; AltName: Full=Rho-type GTPase-activating protein 21; FUNCTION: Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. SUBUNIT: Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1. INTERACTION: P29692:EEF1D; NbExp=2; IntAct=EBI-1642518, EBI-358607; SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. TISSUE SPECIFICITY: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. INDUCTION: Up-regulated upon cell differentiation. PTM: Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes. MISCELLANEOUS: Depletion of ARHGAP21 induces cell spreading and accumulation of F-actin stress fibers. MISCELLANEOUS: Required for In1A-dependent entry of Listeria monocytogenes into cells. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Rho-GAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T5U3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005096 GTPase activator activity GO:0005515 protein binding
Biological Process: GO:0007030 Golgi organization GO:0007165 signal transduction GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction GO:0051683 establishment of Golgi localization GO:0051684 maintenance of Golgi location GO:0072384 organelle transport along microtubule
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