Description: Homo sapiens N-myc (and STAT) interactor (NMI), mRNA. RefSeq Summary (NM_004688): NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr2:152,126,982-152,146,430 Size: 19,449 Total Exon Count: 8 Strand: - Coding Region Position: hg19 chr2:152,127,207-152,139,462 Size: 12,256 Coding Exon Count: 7
ID:NMI_HUMAN DESCRIPTION: RecName: Full=N-myc-interactor; Short=Nmi; AltName: Full=N-myc and STAT interactor; FUNCTION: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. SUBUNIT: Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2. INTERACTION: Q9HCU9:BRMS1; NbExp=2; IntAct=EBI-372942, EBI-714781; Q9XRX5:HHLA3; NbExp=2; IntAct=EBI-372942, EBI-750554; P04198:MYCN; NbExp=3; IntAct=EBI-372942, EBI-878369; P56693:SOX10; NbExp=2; IntAct=EBI-372942, EBI-1167533; O55170:Sox10 (xeno); NbExp=4; IntAct=EBI-372942, EBI-1185693; P51692:STAT5B; NbExp=7; IntAct=EBI-372942, EBI-1186119; Q13748:TUBA3D; NbExp=2; IntAct=EBI-372942, EBI-355068; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver. INDUCTION: By IL2/interleukin-2 and IFNG/IFN-gamma. SIMILARITY: Belongs to the NMI family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13287
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003712 transcription cofactor activity GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0006366 transcription from RNA polymerase II promoter GO:0006954 inflammatory response GO:0007259 JAK-STAT cascade GO:0032480 negative regulation of type I interferon production GO:0045355 negative regulation of interferon-alpha biosynthetic process GO:0045358 negative regulation of interferon-beta biosynthetic process GO:0045824 negative regulation of innate immune response GO:0060333 interferon-gamma-mediated signaling pathway GO:1902524 positive regulation of protein K48-linked ubiquitination