Human Gene QRICH1 (uc003cvv.3)
  Description: Homo sapiens glutamine-rich 1 (QRICH1), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:49,067,142-49,131,504 Size: 64,363 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr3:49,067,885-49,114,450 Size: 46,566 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:49,067,142-49,131,504)mRNA (may differ from genome)Protein (776 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIneXtProt
OMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: QRIC1_HUMAN
DESCRIPTION: RecName: Full=Glutamine-rich protein 1;
SIMILARITY: Contains 1 CARD domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C009505 4,4'-diaminodiphenylmethane
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D002737 Chloroprene
  • D019833 Genistein
  • C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
  • D015739 Nocodazole
  • D017239 Paclitaxel
  • D013749 Tetrachlorodibenzodioxin
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.37 RPKM in Testis
Total median expression: 910.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.90181-0.414 Picture PostScript Text
3' UTR -201.74743-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021893 - DUF3504

Pfam Domains:
PF12012 - Domain of unknown function (DUF3504)

ModBase Predicted Comparative 3D Structure on Q2TAL8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0007275 multicellular organism development
GO:0008150 biological_process
GO:0022604 regulation of cell morphogenesis

Cellular Component:
GO:0005575 cellular_component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  KJ894078 - Synthetic construct Homo sapiens clone ccsbBroadEn_03472 QRICH1 gene, encodes complete protein.
BC110855 - Homo sapiens glutamine-rich 1, mRNA (cDNA clone MGC:131838 IMAGE:6174076), complete cds.
AK025013 - Homo sapiens cDNA: FLJ21360 fis, clone COL02850.
AK000266 - Homo sapiens cDNA FLJ20259 fis, clone COLF7443.
BC098375 - Homo sapiens glutamine-rich 1, mRNA (cDNA clone IMAGE:6168663), partial cds.
BC000978 - Homo sapiens glutamine-rich 1, mRNA (cDNA clone IMAGE:3447148), partial cds.
AK022524 - Homo sapiens cDNA FLJ12462 fis, clone NT2RM1000770, weakly similar to DXS6673E PROTEIN.
JD533362 - Sequence 514386 from Patent EP1572962.
AK124205 - Homo sapiens cDNA FLJ42211 fis, clone THYMU2036461, weakly similar to Homo sapiens zinc finger protein 261 (ZNF261).
AK074313 - Homo sapiens cDNA FLJ23733 fis, clone HEP14786.
JD454841 - Sequence 435865 from Patent EP1572962.
JD199097 - Sequence 180121 from Patent EP1572962.
JD342861 - Sequence 323885 from Patent EP1572962.
JD355086 - Sequence 336110 from Patent EP1572962.
JD191774 - Sequence 172798 from Patent EP1572962.
JD194493 - Sequence 175517 from Patent EP1572962.
JD426828 - Sequence 407852 from Patent EP1572962.
AK292536 - Homo sapiens cDNA FLJ77780 complete cds.
JD325138 - Sequence 306162 from Patent EP1572962.
BC130340 - Homo sapiens glutamine-rich 1, mRNA (cDNA clone MGC:163212 IMAGE:40146371), complete cds.
BC130342 - Homo sapiens glutamine-rich 1, mRNA (cDNA clone MGC:163214 IMAGE:40146373), complete cds.
JD515252 - Sequence 496276 from Patent EP1572962.
JD117968 - Sequence 98992 from Patent EP1572962.
HQ258650 - Synthetic construct Homo sapiens clone IMAGE:100072680 glutamine-rich 1 (QRICH1), transcript variant 2 (QRICH1) gene, encodes complete protein.
AK093259 - Homo sapiens cDNA FLJ35940 fis, clone TESTI2011612, weakly similar to Aegilops squarrosa GAG56D gene for gamma-gliadin, accession CIae 24.
AX748019 - Sequence 1544 from Patent EP1308459.
JD465895 - Sequence 446919 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_198880, NP_942581, Q2TAL8, Q4G0F7, Q7L621, Q8TEA5, QRIC1_HUMAN
UCSC ID: uc003cvv.3
RefSeq Accession: NM_198880
Protein: Q2TAL8 (aka QRIC1_HUMAN)
CCDS: CCDS2787.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198880.1
exon count: 10CDS single in 3' UTR: no RNA size: 3271
ORF size: 2331CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4499.00frame shift in genome: no % Coverage: 99.51
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.