Description: Homo sapiens high mobility group box 1 (HMGB1), mRNA. RefSeq Summary (NM_002128): This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr13:31,032,879-31,040,081 Size: 7,203 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr13:31,035,494-31,037,817 Size: 2,324 Coding Exon Count: 4
ID:HMGB1_HUMAN DESCRIPTION: RecName: Full=High mobility group protein B1; AltName: Full=High mobility group protein 1; Short=HMG-1; FUNCTION: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). SUBUNIT: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Chromosome. SIMILARITY: Belongs to the HMGB family. SIMILARITY: Contains 2 HMG box DNA-binding domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/hmgb1/";
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): HMGB1 CDC HuGE Published Literature: HMGB1 Positive Disease Associations: Alzheimer Disease
, Lipids Related Studies:
Alzheimer Disease S J Furney et al. Molecular psychiatry 2011, Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease., Molecular psychiatry.
[PubMed 21116278]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09429
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK122825 - Homo sapiens cDNA FLJ16428 fis, clone BRACE3008066, highly similar to High mobility group protein B1. CR749614 - Homo sapiens mRNA; cDNA DKFZp686A04236 (from clone DKFZp686A04236). KJ896987 - Synthetic construct Homo sapiens clone ccsbBroadEn_06381 HMGB1 gene, encodes complete protein. JA482248 - Sequence 231 from Patent WO2011072091. JE980540 - Sequence 231 from Patent EP2862929. AL110194 - Homo sapiens mRNA; cDNA DKFZp566M063 (from clone DKFZp566M063). BC141844 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:166986 IMAGE:8860319), complete cds. AK057120 - Homo sapiens cDNA FLJ32558 fis, clone SPLEN1000143, highly similar to High mobility group protein B1. BC030981 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:32637 IMAGE:4041682), complete cds. JD100653 - Sequence 81677 from Patent EP1572962. JD566758 - Sequence 547782 from Patent EP1572962. JD228297 - Sequence 209321 from Patent EP1572962. JD052614 - Sequence 33638 from Patent EP1572962. JD557206 - Sequence 538230 from Patent EP1572962. AK291494 - Homo sapiens cDNA FLJ77690 complete cds, highly similar to Homo sapiens high-mobility group box 1 (HMGB1), mRNA. L13804 - Homo sapiens (clone 06) liver expressed high mobility group 1 protein mRNA, 3' end. BC067732 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:86953 IMAGE:4818524), complete cds. BX647267 - Homo sapiens mRNA; cDNA DKFZp686N1099 (from clone DKFZp686N1099). D63874 - Homo sapiens FM1 mRNA for HMG-1, complete cds. AX795278 - Sequence 1 from Patent WO03051383. BC003378 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:5223 IMAGE:2901382), complete cds. JD551355 - Sequence 532379 from Patent EP1572962. LF337017 - JP 2014500723-A/144520: Polycomb-Associated Non-Coding RNAs. AF401215 - Homo sapiens HMG1 mRNA, 3' untranslated region. BC066889 - Homo sapiens high-mobility group box 1, mRNA (cDNA clone MGC:86954 IMAGE:5268698), complete cds. AB208998 - Homo sapiens mRNA for high-mobility group box 1 variant protein. AK310975 - Homo sapiens cDNA, FLJ18017. JD297262 - Sequence 278286 from Patent EP1572962. X12597 - Human mRNA for high mobility group-1 protein (HMG-1). LF323756 - JP 2014500723-A/131259: Polycomb-Associated Non-Coding RNAs. JD307312 - Sequence 288336 from Patent EP1572962. JD299750 - Sequence 280774 from Patent EP1572962. L13805 - Homo sapiens (clone 06) high mobility group 1 protein mRNA fragment. JD283835 - Sequence 264859 from Patent EP1572962. AY377859 - Homo sapiens high mobility group protein 1 mRNA, complete cds. CR456863 - Homo sapiens full open reading frame cDNA clone RZPDo834D0816D for gene HMGB1, high-mobility group box 1; complete cds, incl. stopcodon. BT006940 - Homo sapiens high-mobility group box 1 mRNA, complete cds. BT020159 - Homo sapiens high-mobility group box 1 mRNA, complete cds. CU678446 - Synthetic construct Homo sapiens gateway clone IMAGE:100016790 5' read HMGB1 mRNA. CU688180 - Synthetic construct Homo sapiens gateway clone IMAGE:100021064 5' read HMGB1 mRNA. BC140013 - Synthetic construct Homo sapiens clone IMAGE:100000676, MGC:167158 high-mobility group box 1 (HMGB1) mRNA, encodes complete protein. BC140018 - Synthetic construct Homo sapiens clone IMAGE:100013567, MGC:167183 high-mobility group box 1 (HMGB1) mRNA, encodes complete protein. AB527489 - Synthetic construct DNA, clone: pF1KB7934, Homo sapiens HMGB1 gene for high-mobility group box 1, without stop codon, in Flexi system. LF317124 - JP 2014500723-A/124627: Polycomb-Associated Non-Coding RNAs. KX821210 - Homo sapiens isolate THM1 high mobility group box 1 (HMGB1) mRNA, partial cds. LF343553 - JP 2014500723-A/151056: Polycomb-Associated Non-Coding RNAs. LF343357 - JP 2014500723-A/150860: Polycomb-Associated Non-Coding RNAs. LF372070 - JP 2014500723-A/179573: Polycomb-Associated Non-Coding RNAs. LF361953 - JP 2014500723-A/169456: Polycomb-Associated Non-Coding RNAs. LF366776 - JP 2014500723-A/174279: Polycomb-Associated Non-Coding RNAs. LF370158 - JP 2014500723-A/177661: Polycomb-Associated Non-Coding RNAs. LF371918 - JP 2014500723-A/179421: Polycomb-Associated Non-Coding RNAs. LF365203 - JP 2014500723-A/172706: Polycomb-Associated Non-Coding RNAs. LF336970 - JP 2014500723-A/144473: Polycomb-Associated Non-Coding RNAs. LF343160 - JP 2014500723-A/150663: Polycomb-Associated Non-Coding RNAs. LF345325 - JP 2014500723-A/152828: Polycomb-Associated Non-Coding RNAs. LF343393 - JP 2014500723-A/150896: Polycomb-Associated Non-Coding RNAs. LF331940 - JP 2014500723-A/139443: Polycomb-Associated Non-Coding RNAs. LF317744 - JP 2014500723-A/125247: Polycomb-Associated Non-Coding RNAs. LF317125 - JP 2014500723-A/124628: Polycomb-Associated Non-Coding RNAs. LF325343 - JP 2014500723-A/132846: Polycomb-Associated Non-Coding RNAs. AK304506 - Homo sapiens cDNA FLJ56337 complete cds, highly similar to High mobility group protein B1. LF323755 - JP 2014500723-A/131258: Polycomb-Associated Non-Coding RNAs. LF361954 - JP 2014500723-A/169457: Polycomb-Associated Non-Coding RNAs. LF366040 - JP 2014500723-A/173543: Polycomb-Associated Non-Coding RNAs. KX821209 - Homo sapiens isolate CHM1 high mobility group box 1 (HMGB1) mRNA, partial cds. LF372071 - JP 2014500723-A/179574: Polycomb-Associated Non-Coding RNAs. LF334605 - JP 2014500723-A/142108: Polycomb-Associated Non-Coding RNAs. LF375440 - JP 2014500723-A/182943: Polycomb-Associated Non-Coding RNAs. JD343525 - Sequence 324549 from Patent EP1572962. JD484349 - Sequence 465373 from Patent EP1572962. MA559333 - JP 2018138019-A/131259: Polycomb-Associated Non-Coding RNAs. MA579130 - JP 2018138019-A/151056: Polycomb-Associated Non-Coding RNAs. MA578934 - JP 2018138019-A/150860: Polycomb-Associated Non-Coding RNAs. MA607647 - JP 2018138019-A/179573: Polycomb-Associated Non-Coding RNAs. MA602353 - JP 2018138019-A/174279: Polycomb-Associated Non-Coding RNAs. MA605735 - JP 2018138019-A/177661: Polycomb-Associated Non-Coding RNAs. MA607495 - JP 2018138019-A/179421: Polycomb-Associated Non-Coding RNAs. MA600780 - JP 2018138019-A/172706: Polycomb-Associated Non-Coding RNAs. MA578737 - JP 2018138019-A/150663: Polycomb-Associated Non-Coding RNAs. MA580902 - JP 2018138019-A/152828: Polycomb-Associated Non-Coding RNAs. MA578970 - JP 2018138019-A/150896: Polycomb-Associated Non-Coding RNAs. MA567517 - JP 2018138019-A/139443: Polycomb-Associated Non-Coding RNAs. MA560920 - JP 2018138019-A/132846: Polycomb-Associated Non-Coding RNAs. MA559332 - JP 2018138019-A/131258: Polycomb-Associated Non-Coding RNAs. MA601617 - JP 2018138019-A/173543: Polycomb-Associated Non-Coding RNAs. MA607648 - JP 2018138019-A/179574: Polycomb-Associated Non-Coding RNAs. MA572594 - JP 2018138019-A/144520: Polycomb-Associated Non-Coding RNAs. MA552701 - JP 2018138019-A/124627: Polycomb-Associated Non-Coding RNAs. MA597530 - JP 2018138019-A/169456: Polycomb-Associated Non-Coding RNAs. MA572547 - JP 2018138019-A/144473: Polycomb-Associated Non-Coding RNAs. MA553321 - JP 2018138019-A/125247: Polycomb-Associated Non-Coding RNAs. MA552702 - JP 2018138019-A/124628: Polycomb-Associated Non-Coding RNAs. MA597531 - JP 2018138019-A/169457: Polycomb-Associated Non-Coding RNAs. MA570182 - JP 2018138019-A/142108: Polycomb-Associated Non-Coding RNAs. MA611017 - JP 2018138019-A/182943: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03410 - Base excision repair
BioCarta from NCI Cancer Genome Anatomy Project h_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis h_pcafpathway - The information-processing pathway at the IFN-beta enhancer
Reactome (by CSHL, EBI, and GO)
Protein P09429 (Reactome details) participates in the following event(s):