Description: Homo sapiens inositol hexakisphosphate kinase 1 (IP6K1), transcript variant 1, mRNA. RefSeq Summary (NM_153273): This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]. Transcript (Including UTRs) Position: hg19 chr3:49,761,728-49,823,973 Size: 62,246 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr3:49,764,555-49,785,473 Size: 20,919 Coding Exon Count: 5
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92551
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
D87452 - Homo sapiens KIAA0263 mRNA for KIAA0263 protein. AK295689 - Homo sapiens cDNA FLJ57373 complete cds, highly similar to Inositol hexaphosphate kinase 1 (EC 2.7.4.21). JD540112 - Sequence 521136 from Patent EP1572962. JD140843 - Sequence 121867 from Patent EP1572962. JD424748 - Sequence 405772 from Patent EP1572962. DQ589929 - Homo sapiens piRNA piR-57041, complete sequence. JD024111 - Sequence 5135 from Patent EP1572962. JD028286 - Sequence 9310 from Patent EP1572962. JD565627 - Sequence 546651 from Patent EP1572962. JD272690 - Sequence 253714 from Patent EP1572962. DQ598859 - Homo sapiens piRNA piR-36925, complete sequence. JD024222 - Sequence 5246 from Patent EP1572962. JD030008 - Sequence 11032 from Patent EP1572962. JD209242 - Sequence 190266 from Patent EP1572962. JD222034 - Sequence 203058 from Patent EP1572962. JD135070 - Sequence 116094 from Patent EP1572962. DQ597577 - Homo sapiens piRNA piR-35643, complete sequence. DQ585953 - Homo sapiens piRNA piR-53065, complete sequence. AK289772 - Homo sapiens cDNA FLJ76219 complete cds, highly similar to Homo sapiens inositol hexaphosphate kinase 1 (IHPK1), transcriptvariant 1, mRNA. DQ579995 - Homo sapiens piRNA piR-48107, complete sequence. BC012944 - Homo sapiens inositol hexakisphosphate kinase 1, mRNA (cDNA clone MGC:9925 IMAGE:3872311), complete cds. DQ578911 - Homo sapiens piRNA piR-47023, complete sequence. KJ898097 - Synthetic construct Homo sapiens clone ccsbBroadEn_07491 IP6K1 gene, encodes complete protein. KJ905382 - Synthetic construct Homo sapiens clone ccsbBroadEn_14946 IP6K1 gene, encodes complete protein. AB383825 - Synthetic construct DNA, clone: pF1KSDA0263, Homo sapiens IHPK1 gene for inositol hexaphosphate kinase 1, complete cds, without stop codon, in Flexi system. JD444445 - Sequence 425469 from Patent EP1572962. JD119820 - Sequence 100844 from Patent EP1572962. JD282793 - Sequence 263817 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92551 (Reactome details) participates in the following event(s):
R-HSA-1855227 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol R-HSA-1855223 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol R-HSA-1855193 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol R-HSA-1855158 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol R-HSA-1855194 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol R-HSA-1855157 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus R-HSA-1855207 IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus R-HSA-1855230 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus R-HSA-1855224 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus R-HSA-1855181 I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus R-HSA-1855167 Synthesis of pyrophosphates in the cytosol R-HSA-1855191 Synthesis of IPs in the nucleus R-HSA-1483249 Inositol phosphate metabolism R-HSA-1430728 Metabolism