Description: Homo sapiens phosphopantothenoylcysteine decarboxylase (PPCDC), mRNA. RefSeq Summary (NM_021823): Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg19 chr15:75,315,927-75,343,067 Size: 27,141 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr15:75,320,660-75,341,576 Size: 20,917 Coding Exon Count: 5
ID:COAC_HUMAN DESCRIPTION: RecName: Full=Phosphopantothenoylcysteine decarboxylase; Short=PPC-DC; EC=4.1.1.36; AltName: Full=CoaC; FUNCTION: Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine. CATALYTIC ACTIVITY: N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO(2). COFACTOR: Binds 1 FMN per subunit. PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. SUBUNIT: Homotrimer (Potential). SIMILARITY: Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PPCDC CDC HuGE Published Literature: PPCDC Positive Disease Associations: Body Height
, Caffeine Related Studies:
Caffeine Marilyn C Cornelis et al. PLoS genetics 2011, Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption., PLoS genetics.
[PubMed 21490707]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96CD2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.