Human Gene ADGRD1 (uc001uit.4)
  Description: Homo sapiens G protein-coupled receptor 133 (ADGRD1), mRNA.
RefSeq Summary (NM_198827): The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010].
Transcript (Including UTRs)
   Position: hg19 chr12:131,438,452-131,626,008 Size: 187,557 Total Exon Count: 25 Strand: +
Coding Region
   Position: hg19 chr12:131,439,011-131,623,808 Size: 184,798 Coding Exon Count: 25 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:131,438,452-131,626,008)mRNA (may differ from genome)Protein (874 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMalacardsMGIneXtProt
OMIMPubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP133_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 133; AltName: Full=G-protein coupled receptor PGR25; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRD1
Diseases sorted by gene-association score: glioblastoma (4)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.10 RPKM in Heart - Atrial Appendage
Total median expression: 259.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -191.21559-0.342 Picture PostScript Text
3' UTR -896.642200-0.408 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif
PF05462 - Slime mold cyclic AMP receptor
PF13385 - Concanavalin A-like lectin/glucanases superfamily

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases

ModBase Predicted Comparative 3D Structure on Q6QNK2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ906476 - Synthetic construct Homo sapiens clone ccsbBroadEn_16146 GPR133 gene, encodes complete protein.
BX649116 - Homo sapiens mRNA; cDNA DKFZp686M24109 (from clone DKFZp686M24109).
AY532280 - Homo sapiens G protein coupled receptor 133 (GPR133) mRNA, complete cds.
EU523118 - Homo sapiens G protein coupled receptor 133 variant 2 (GPR133) mRNA, complete cds, alternatively spliced.
BC112307 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:138512 IMAGE:8327775), complete cds.
BC112309 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:138514 IMAGE:8327777), complete cds.
BC143775 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:177306 IMAGE:9052289), complete cds.
AK131538 - Homo sapiens cDNA FLJ16770 fis, clone BRAWH3028645, weakly similar to Rattus norvegicus CL1BA protein (CL1BA).
AY255587 - Homo sapiens G protein-coupled receptor PGR25 mRNA, partial cds.
AL162032 - Homo sapiens mRNA; cDNA DKFZp434B1272 (from clone DKFZp434B1272); partial cds.
AY278561 - Homo sapiens G-protein coupled receptor GPR133 (GPR133) mRNA, complete cds.
BC047951 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone IMAGE:5766895), partial cds.
JD404139 - Sequence 385163 from Patent EP1572962.
JD416967 - Sequence 397991 from Patent EP1572962.
JD547794 - Sequence 528818 from Patent EP1572962.
JD283048 - Sequence 264072 from Patent EP1572962.
JD218341 - Sequence 199365 from Patent EP1572962.
JD464473 - Sequence 445497 from Patent EP1572962.
JD523228 - Sequence 504252 from Patent EP1572962.
JD396812 - Sequence 377836 from Patent EP1572962.
JD466831 - Sequence 447855 from Patent EP1572962.
HQ258637 - Synthetic construct Homo sapiens clone IMAGE:100073193 Unknown protein gene, encodes complete protein.
JD475764 - Sequence 456788 from Patent EP1572962.
JD380143 - Sequence 361167 from Patent EP1572962.
JD116434 - Sequence 97458 from Patent EP1572962.
JD132764 - Sequence 113788 from Patent EP1572962.
JD144419 - Sequence 125443 from Patent EP1572962.
JD180862 - Sequence 161886 from Patent EP1572962.
JD495688 - Sequence 476712 from Patent EP1572962.
JD182859 - Sequence 163883 from Patent EP1572962.
JD133319 - Sequence 114343 from Patent EP1572962.
JD076253 - Sequence 57277 from Patent EP1572962.
JD530797 - Sequence 511821 from Patent EP1572962.
JD211714 - Sequence 192738 from Patent EP1572962.
JD443493 - Sequence 424517 from Patent EP1572962.
JD445168 - Sequence 426192 from Patent EP1572962.
JD422758 - Sequence 403782 from Patent EP1572962.
JD471083 - Sequence 452107 from Patent EP1572962.
JD133565 - Sequence 114589 from Patent EP1572962.
JD282039 - Sequence 263063 from Patent EP1572962.
JD070631 - Sequence 51655 from Patent EP1572962.
JD232484 - Sequence 213508 from Patent EP1572962.
JD346900 - Sequence 327924 from Patent EP1572962.
JD540977 - Sequence 522001 from Patent EP1572962.
JD483086 - Sequence 464110 from Patent EP1572962.
JD202068 - Sequence 183092 from Patent EP1572962.
JD318071 - Sequence 299095 from Patent EP1572962.
JD173088 - Sequence 154112 from Patent EP1572962.
JD355107 - Sequence 336131 from Patent EP1572962.
JD482112 - Sequence 463136 from Patent EP1572962.
JD470497 - Sequence 451521 from Patent EP1572962.
JD297053 - Sequence 278077 from Patent EP1572962.
JD501425 - Sequence 482449 from Patent EP1572962.
JD187988 - Sequence 169012 from Patent EP1572962.
JD276254 - Sequence 257278 from Patent EP1572962.
JD091005 - Sequence 72029 from Patent EP1572962.
JD439538 - Sequence 420562 from Patent EP1572962.
JD040989 - Sequence 22013 from Patent EP1572962.
JD378525 - Sequence 359549 from Patent EP1572962.
JD311445 - Sequence 292469 from Patent EP1572962.
JD504163 - Sequence 485187 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: GP133_HUMAN, GPR133, NM_198827, NP_942122, PGR25, Q2M1L3, Q6QNK2, Q6ZMQ1, Q7Z7M2, Q86SM4
UCSC ID: uc001uit.4
RefSeq Accession: NM_198827
Protein: Q6QNK2 (aka GP133_HUMAN)
CCDS: CCDS9272.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198827.3
exon count: 25CDS single in 3' UTR: no RNA size: 5392
ORF size: 2625CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5420.00frame shift in genome: no % Coverage: 99.85
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.