Human Gene ADGRD1 (uc001uit.4)
Description: Homo sapiens G protein-coupled receptor 133 (ADGRD1), mRNA.
RefSeq Summary (NM_198827): The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010].
Transcript (Including UTRs)
Position: hg19 chr12:131,438,452-131,626,008 Size: 187,557 Total Exon Count: 25 Strand: +
Coding Region
Position: hg19 chr12:131,439,011-131,623,808 Size: 184,798 Coding Exon Count: 25
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: GP133_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 133; AltName: Full=G-protein coupled receptor PGR25; Flags: Precursor;
FUNCTION: Orphan receptor.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.SIMILARITY: Contains 1 GPS domain.
Primer design for this transcript
MalaCards Disease Associations
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR017983 - GPCR_2_secretin-like_CS
IPR000203 - GPS_dom
Pfam Domains: PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif
PF05462 - Slime mold cyclic AMP receptor
PF13385 - Concanavalin A-like lectin/glucanases superfamily
SCOP Domains: 49899 - Concanavalin A-like lectins/glucanases
ModBase Predicted Comparative 3D Structure on Q6QNK2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
KJ906476 - Synthetic construct Homo sapiens clone ccsbBroadEn_16146 GPR133 gene, encodes complete protein.BX649116 - Homo sapiens mRNA; cDNA DKFZp686M24109 (from clone DKFZp686M24109).AY532280 - Homo sapiens G protein coupled receptor 133 (GPR133) mRNA, complete cds.EU523118 - Homo sapiens G protein coupled receptor 133 variant 2 (GPR133) mRNA, complete cds, alternatively spliced.BC112307 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:138512 IMAGE:8327775), complete cds.BC112309 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:138514 IMAGE:8327777), complete cds.BC143775 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone MGC:177306 IMAGE:9052289), complete cds.AK131538 - Homo sapiens cDNA FLJ16770 fis, clone BRAWH3028645, weakly similar to Rattus norvegicus CL1BA protein (CL1BA).AY255587 - Homo sapiens G protein-coupled receptor PGR25 mRNA, partial cds.AL162032 - Homo sapiens mRNA; cDNA DKFZp434B1272 (from clone DKFZp434B1272); partial cds.AY278561 - Homo sapiens G-protein coupled receptor GPR133 (GPR133) mRNA, complete cds.BC047951 - Homo sapiens G protein-coupled receptor 133, mRNA (cDNA clone IMAGE:5766895), partial cds.JD404139 - Sequence 385163 from Patent EP1572962.JD416967 - Sequence 397991 from Patent EP1572962.JD547794 - Sequence 528818 from Patent EP1572962.JD283048 - Sequence 264072 from Patent EP1572962.JD218341 - Sequence 199365 from Patent EP1572962.JD464473 - Sequence 445497 from Patent EP1572962.JD523228 - Sequence 504252 from Patent EP1572962.JD396812 - Sequence 377836 from Patent EP1572962.JD466831 - Sequence 447855 from Patent EP1572962.HQ258637 - Synthetic construct Homo sapiens clone IMAGE:100073193 Unknown protein gene, encodes complete protein.JD475764 - Sequence 456788 from Patent EP1572962.JD380143 - Sequence 361167 from Patent EP1572962.JD116434 - Sequence 97458 from Patent EP1572962.JD132764 - Sequence 113788 from Patent EP1572962.JD144419 - Sequence 125443 from Patent EP1572962.JD180862 - Sequence 161886 from Patent EP1572962.JD495688 - Sequence 476712 from Patent EP1572962.JD182859 - Sequence 163883 from Patent EP1572962.JD133319 - Sequence 114343 from Patent EP1572962.JD076253 - Sequence 57277 from Patent EP1572962.JD530797 - Sequence 511821 from Patent EP1572962.JD211714 - Sequence 192738 from Patent EP1572962.JD443493 - Sequence 424517 from Patent EP1572962.JD445168 - Sequence 426192 from Patent EP1572962.JD422758 - Sequence 403782 from Patent EP1572962.JD471083 - Sequence 452107 from Patent EP1572962.JD133565 - Sequence 114589 from Patent EP1572962.JD282039 - Sequence 263063 from Patent EP1572962.JD070631 - Sequence 51655 from Patent EP1572962.JD232484 - Sequence 213508 from Patent EP1572962.JD346900 - Sequence 327924 from Patent EP1572962.JD540977 - Sequence 522001 from Patent EP1572962.JD483086 - Sequence 464110 from Patent EP1572962.JD202068 - Sequence 183092 from Patent EP1572962.JD318071 - Sequence 299095 from Patent EP1572962.JD173088 - Sequence 154112 from Patent EP1572962.JD355107 - Sequence 336131 from Patent EP1572962.JD482112 - Sequence 463136 from Patent EP1572962.JD470497 - Sequence 451521 from Patent EP1572962.JD297053 - Sequence 278077 from Patent EP1572962.JD501425 - Sequence 482449 from Patent EP1572962.JD187988 - Sequence 169012 from Patent EP1572962.JD276254 - Sequence 257278 from Patent EP1572962.JD091005 - Sequence 72029 from Patent EP1572962.JD439538 - Sequence 420562 from Patent EP1572962.JD040989 - Sequence 22013 from Patent EP1572962.JD378525 - Sequence 359549 from Patent EP1572962.JD311445 - Sequence 292469 from Patent EP1572962.JD504163 - Sequence 485187 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: GP133_HUMAN, GPR133, NM_198827, NP_942122, PGR25, Q2M1L3, Q6QNK2, Q6ZMQ1, Q7Z7M2, Q86SM4UCSC ID: uc001uit.4RefSeq Accession: NM_198827
Protein: Q6QNK2
(aka GP133_HUMAN)
CCDS: CCDS9272.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_198827.3
exon count:
25 CDS single in 3' UTR:
no
RNA size:
5392
ORF size:
2625 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
5420.00 frame shift in genome:
no
% Coverage:
99.85
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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