Human Gene NCBP3 (uc010ckl.2)
  Description: Homo sapiens chromosome 17 open reading frame 85 (NCBP3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:3,710,045-3,749,545 Size: 39,501 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr17:3,716,338-3,749,517 Size: 33,180 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:3,710,045-3,749,545)mRNA (may differ from genome)Protein (620 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CQ085_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C17orf85; AltName: Full=Protein ELG;
SEQUENCE CAUTION: Sequence=BAD97190.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.95 RPKM in Nerve - Tibial
Total median expression: 421.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.0028-0.286 Picture PostScript Text
3' UTR -2015.716293-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019416 - DUF2414
IPR012677 - Nucleotide-bd_a/b_plait

Pfam Domains:
PF10309 - Nuclear cap-binding protein subunit 3

ModBase Predicted Comparative 3D Structure on Q53F19
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding

Biological Process:
GO:0006370 7-methylguanosine mRNA capping
GO:0006397 mRNA processing
GO:0051028 mRNA transport
GO:0051607 defense response to virus

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0034518 RNA cap binding complex


-  Descriptions from all associated GenBank mRNAs
  AK056724 - Homo sapiens cDNA FLJ32162 fis, clone PLACE6000325.
JD024568 - Sequence 5592 from Patent EP1572962.
JD029316 - Sequence 10340 from Patent EP1572962.
JD029598 - Sequence 10622 from Patent EP1572962.
JD517599 - Sequence 498623 from Patent EP1572962.
JD379591 - Sequence 360615 from Patent EP1572962.
DQ585260 - Homo sapiens piRNA piR-52372, complete sequence.
JD115483 - Sequence 96507 from Patent EP1572962.
DQ580982 - Homo sapiens piRNA piR-49094, complete sequence.
DQ588260 - Homo sapiens piRNA piR-55372, complete sequence.
LF384763 - JP 2014500723-A/192266: Polycomb-Associated Non-Coding RNAs.
AJ277841 - Homo sapiens mRNA for ELG protein.
AK125048 - Homo sapiens cDNA FLJ43058 fis, clone BRTHA3007472, highly similar to Homo sapiens ELG protein (HSA277841), mRNA.
JD053229 - Sequence 34253 from Patent EP1572962.
JD278566 - Sequence 259590 from Patent EP1572962.
JD093643 - Sequence 74667 from Patent EP1572962.
JD499405 - Sequence 480429 from Patent EP1572962.
JD487786 - Sequence 468810 from Patent EP1572962.
JD376924 - Sequence 357948 from Patent EP1572962.
JD386256 - Sequence 367280 from Patent EP1572962.
BC010707 - Homo sapiens chromosome 17 open reading frame 85, mRNA (cDNA clone IMAGE:3853688), partial cds.
JD090497 - Sequence 71521 from Patent EP1572962.
JD431372 - Sequence 412396 from Patent EP1572962.
JD408785 - Sequence 389809 from Patent EP1572962.
JD236846 - Sequence 217870 from Patent EP1572962.
JD203397 - Sequence 184421 from Patent EP1572962.
JD217303 - Sequence 198327 from Patent EP1572962.
JD484850 - Sequence 465874 from Patent EP1572962.
JD101387 - Sequence 82411 from Patent EP1572962.
AK223470 - Homo sapiens mRNA for ELG protein variant, clone: FCC117H02.
JD265647 - Sequence 246671 from Patent EP1572962.
JD403748 - Sequence 384772 from Patent EP1572962.
JD192456 - Sequence 173480 from Patent EP1572962.
JD506511 - Sequence 487535 from Patent EP1572962.
JD192502 - Sequence 173526 from Patent EP1572962.
JD444563 - Sequence 425587 from Patent EP1572962.
JD431440 - Sequence 412464 from Patent EP1572962.
JD053215 - Sequence 34239 from Patent EP1572962.
JD157428 - Sequence 138452 from Patent EP1572962.
BC146419 - Synthetic construct Homo sapiens clone IMAGE:100015138, MGC:180218 chromosome 17 open reading frame 85 (C17orf85) mRNA, encodes complete protein.
BC148856 - Synthetic construct Homo sapiens clone IMAGE:100015934, MGC:183220 chromosome 17 open reading frame 85 (C17orf85) mRNA, encodes complete protein.
AB463511 - Synthetic construct DNA, clone: pF1KB7392, Homo sapiens C17orf85 gene for chromosome 17 open reading frame 85, without stop codon, in Flexi system.
LF326687 - JP 2014500723-A/134190: Polycomb-Associated Non-Coding RNAs.
LF326686 - JP 2014500723-A/134189: Polycomb-Associated Non-Coding RNAs.
LF326685 - JP 2014500723-A/134188: Polycomb-Associated Non-Coding RNAs.
LF326682 - JP 2014500723-A/134185: Polycomb-Associated Non-Coding RNAs.
LF326681 - JP 2014500723-A/134184: Polycomb-Associated Non-Coding RNAs.
LF326680 - JP 2014500723-A/134183: Polycomb-Associated Non-Coding RNAs.
LF326679 - JP 2014500723-A/134182: Polycomb-Associated Non-Coding RNAs.
LF326678 - JP 2014500723-A/134181: Polycomb-Associated Non-Coding RNAs.
LF326677 - JP 2014500723-A/134180: Polycomb-Associated Non-Coding RNAs.
BC011733 - Homo sapiens ELG protein, mRNA (cDNA clone IMAGE:4336646), partial cds.
LF326674 - JP 2014500723-A/134177: Polycomb-Associated Non-Coding RNAs.
LF326673 - JP 2014500723-A/134176: Polycomb-Associated Non-Coding RNAs.
LF326672 - JP 2014500723-A/134175: Polycomb-Associated Non-Coding RNAs.
LF326671 - JP 2014500723-A/134174: Polycomb-Associated Non-Coding RNAs.
LF326668 - JP 2014500723-A/134171: Polycomb-Associated Non-Coding RNAs.
LF326667 - JP 2014500723-A/134170: Polycomb-Associated Non-Coding RNAs.
MA620340 - JP 2018138019-A/192266: Polycomb-Associated Non-Coding RNAs.
MA562264 - JP 2018138019-A/134190: Polycomb-Associated Non-Coding RNAs.
MA562263 - JP 2018138019-A/134189: Polycomb-Associated Non-Coding RNAs.
MA562262 - JP 2018138019-A/134188: Polycomb-Associated Non-Coding RNAs.
MA562259 - JP 2018138019-A/134185: Polycomb-Associated Non-Coding RNAs.
MA562258 - JP 2018138019-A/134184: Polycomb-Associated Non-Coding RNAs.
MA562257 - JP 2018138019-A/134183: Polycomb-Associated Non-Coding RNAs.
MA562256 - JP 2018138019-A/134182: Polycomb-Associated Non-Coding RNAs.
MA562255 - JP 2018138019-A/134181: Polycomb-Associated Non-Coding RNAs.
MA562254 - JP 2018138019-A/134180: Polycomb-Associated Non-Coding RNAs.
MA562251 - JP 2018138019-A/134177: Polycomb-Associated Non-Coding RNAs.
MA562250 - JP 2018138019-A/134176: Polycomb-Associated Non-Coding RNAs.
MA562249 - JP 2018138019-A/134175: Polycomb-Associated Non-Coding RNAs.
MA562248 - JP 2018138019-A/134174: Polycomb-Associated Non-Coding RNAs.
MA562245 - JP 2018138019-A/134171: Polycomb-Associated Non-Coding RNAs.
MA562244 - JP 2018138019-A/134170: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KWG7, C17orf85, CQ085_HUMAN, NM_001114118, NP_001107590, Q53F19, Q7L406, Q96FK1, Q9NXZ4, uc010ckl.1
UCSC ID: uc010ckl.2
RefSeq Accession: NM_001114118
Protein: Q53F19 (aka CQ085_HUMAN)
CCDS: CCDS45578.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001114118.2
exon count: 13CDS single in 3' UTR: no RNA size: 8197
ORF size: 1863CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3851.00frame shift in genome: no % Coverage: 99.84
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.