Description: Homo sapiens grainyhead-like 1 (Drosophila) (GRHL1), mRNA. RefSeq Summary (NM_198182): This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr2:10,091,792-10,142,412 Size: 50,621 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr2:10,091,963-10,140,835 Size: 48,873 Coding Exon Count: 16
ID:GRHL1_HUMAN DESCRIPTION: RecName: Full=Grainyhead-like protein 1 homolog; AltName: Full=Mammalian grainyhead; AltName: Full=NH32; AltName: Full=Transcription factor CP2-like 2; AltName: Full=Transcription factor LBP-32; FUNCTION: Transcription factor. Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. May play a role in development. May be involved in epidermal differentiation (By similarity). Binds and transactivates the EN1 promoter. SUBUNIT: Homodimer, also forms heterodimers with GRHL2 or GRHL3. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Highly expressed in placental JEG-3 cells and at very low levels in non-steroidogenic cells. No expression detected in adrenal NCI-H295A cells. DEVELOPMENTAL STAGE: Expressed in fetal liver and brain. SIMILARITY: Belongs to the grh/CP2 family. Grainyhead subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZI5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0005515 protein binding GO:0031490 chromatin DNA binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0002934 desmosome organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0008544 epidermis development GO:0019216 regulation of lipid metabolic process GO:0045616 regulation of keratinocyte differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0061436 establishment of skin barrier
US Server
