Human Gene ANGPT4 (uc002wei.3) Description and Page Index
  Description: Homo sapiens angiopoietin 4 (ANGPT4), mRNA.
RefSeq Summary (NM_015985): Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF074332.1, SRR1803611.235771.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2156099 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381922.5/ ENSP00000371347.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr20:853,297-896,960 Size: 43,664 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr20:853,603-896,857 Size: 43,255 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:853,297-896,960)mRNA (may differ from genome)Protein (503 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Angiopoietin-4; Short=ANG-4; AltName: Full=Angiopoietin-3; Short=ANG-3; Flags: Precursor;
FUNCTION: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
SUBUNIT: Homodimer; disulfide-linked. Interacts with TEK/TIE2.
SUBCELLULAR LOCATION: Secreted (Probable).
TISSUE SPECIFICITY: Highly expressed in the lung with much lower levels found in other tissues.
SIMILARITY: Contains 1 fibrinogen C-terminal domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ANGPT4
CDC HuGE Published Literature: ANGPT4

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.19 RPKM in Adipose - Subcutaneous
Total median expression: 29.21 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.90103-0.310 Picture PostScript Text
3' UTR -112.54306-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002181 - Fibrinogen_a/b/g_C
IPR014716 - Fibrinogen_a/b/g_C_1
IPR014715 - Fibrinogen_a/b/g_C_2
IPR020837 - Fibrinogen_CS

Pfam Domains:
PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain

SCOP Domains:
56496 - Fibrinogen C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9Y264
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
   Protein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030971 receptor tyrosine kinase binding

Biological Process:
GO:0001525 angiogenesis
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007219 Notch signaling pathway
GO:0010595 positive regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0071456 cellular response to hypoxia
GO:0001935 endothelial cell proliferation

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space

-  Descriptions from all associated GenBank mRNAs
  AF074332 - Homo sapiens angiopoietin-3 (ANG-3) mRNA, complete cds.
JD519700 - Sequence 500724 from Patent EP1572962.
JD259257 - Sequence 240281 from Patent EP1572962.
JD154014 - Sequence 135038 from Patent EP1572962.
JD225788 - Sequence 206812 from Patent EP1572962.
AK304756 - Homo sapiens cDNA FLJ59224 complete cds, highly similar to Angiopoietin-4 precursor.
JD430737 - Sequence 411761 from Patent EP1572962.
JD470467 - Sequence 451491 from Patent EP1572962.
JD185507 - Sequence 166531 from Patent EP1572962.
BC111976 - Homo sapiens angiopoietin 4, mRNA (cDNA clone MGC:138181 IMAGE:8327444), complete cds.
BC111978 - Homo sapiens angiopoietin 4, mRNA (cDNA clone MGC:138183 IMAGE:8327446), complete cds.
AF113708 - Homo sapiens angiopoietin 4 (ANG4) mRNA, partial cds.
AB527108 - Synthetic construct DNA, clone: pF1KE0348, Homo sapiens ANGPT4 gene for angiopoietin 4, without stop codon, in Flexi system.
BC111922 - Synthetic construct Homo sapiens clone IMAGE:40080756, MGC:133469 ANGPT4 protein (ANGPT4) mRNA, encodes complete protein.
BC118495 - Synthetic construct Homo sapiens clone IMAGE:40080764, MGC:155337 ANGPT4 protein (ANGPT4) mRNA, encodes complete protein.
JD310407 - Sequence 291431 from Patent EP1572962.
JD452887 - Sequence 433911 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y264 (Reactome details) participates in the following event(s):

R-HSA-204824 Interaction of Tie2 and Ang4
R-HSA-210993 Tie2 Signaling
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: ANG3, ANG4, ANGP4_HUMAN, NM_015985, NP_057069, Q5TFF4, Q9H4Z4, Q9Y264
UCSC ID: uc002wei.3
RefSeq Accession: NM_015985
Protein: Q9Y264 (aka ANGP4_HUMAN or AGP4_HUMAN)
CCDS: CCDS13009.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_015985.2
exon count: 9CDS single in 3' UTR: no RNA size: 1955
ORF size: 1512CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3179.00frame shift in genome: no % Coverage: 98.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.