Human Gene METTL2A (uc002izv.2)
Description: Homo sapiens methyltransferase like 2A (METTL2A), mRNA.
Transcript (Including UTRs)
Position: hg19 chr17:60,501,246-60,527,454 Size: 26,209 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr17:60,501,264-60,526,090 Size: 24,827 Coding Exon Count: 9
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MET2A_HUMAN
DESCRIPTION: RecName: Full=Methyltransferase-like protein 2A; EC=2.1.1.-;
FUNCTION: Probable methyltransferase (By similarity).SIMILARITY: Belongs to the methyltransferase superfamily. METL family.SEQUENCE CAUTION: Sequence=BAB14260.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR026113 - MeTrfase
IPR017280 - MeTrfase_METTL2_prd
Pfam Domains: PF01209 - ubiE/COQ5 methyltransferase family
PF08241 - Methyltransferase domain
PF08242 - Methyltransferase domain
PF13489 - Methyltransferase domain
PF13649 - Methyltransferase domain
PF13847 - Methyltransferase domain
SCOP Domains: 53335 - S-adenosyl-L-methionine-dependent methyltransferases
ModBase Predicted Comparative 3D Structure on Q96IZ6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC006985 - Homo sapiens methyltransferase like 2A, mRNA (cDNA clone MGC:12209 IMAGE:3930328), complete cds.AB590991 - Synthetic construct DNA, clone: pFN21AE1857, Homo sapiens METTL2A gene for methyltransferase like 2A, without stop codon, in Flexi system.JD395176 - Sequence 376200 from Patent EP1572962.JD395177 - Sequence 376201 from Patent EP1572962.AF161384 - Homo sapiens HSPC266 mRNA, partial cds.AK022822 - Homo sapiens cDNA FLJ12760 fis, clone NT2RP2001366.AF161385 - Homo sapiens HSPC267 mRNA, partial cds.JD332144 - Sequence 313168 from Patent EP1572962.JD139370 - Sequence 120394 from Patent EP1572962.JF432470 - Synthetic construct Homo sapiens clone IMAGE:100073691 methyltransferase like 2A (METTL2A) gene, encodes complete protein.KJ904190 - Synthetic construct Homo sapiens clone ccsbBroadEn_13584 METTL2A gene, encodes complete protein.AK000991 - Homo sapiens cDNA FLJ10129 fis, clone HEMBA1003033, highly similar to Methyltransferase-like protein 2 (EC 2.1.1.-).JD335977 - Sequence 317001 from Patent EP1572962.JD364809 - Sequence 345833 from Patent EP1572962.JD546275 - Sequence 527299 from Patent EP1572962.JD221877 - Sequence 202901 from Patent EP1572962.JD455061 - Sequence 436085 from Patent EP1572962.JD537302 - Sequence 518326 from Patent EP1572962.JD194649 - Sequence 175673 from Patent EP1572962.JD135702 - Sequence 116726 from Patent EP1572962.JD238288 - Sequence 219312 from Patent EP1572962.JD324495 - Sequence 305519 from Patent EP1572962.JD180020 - Sequence 161044 from Patent EP1572962.JD380242 - Sequence 361266 from Patent EP1572962.DQ598947 - Homo sapiens piRNA piR-37013, complete sequence.JD359313 - Sequence 340337 from Patent EP1572962.JD564242 - Sequence 545266 from Patent EP1572962.JD537067 - Sequence 518091 from Patent EP1572962.JD257030 - Sequence 238054 from Patent EP1572962.JD514937 - Sequence 495961 from Patent EP1572962.JD472424 - Sequence 453448 from Patent EP1572962.JD421484 - Sequence 402508 from Patent EP1572962.JD179105 - Sequence 160129 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6NNC4, HSPC266, MET2A_HUMAN, METTL2, NM_181725, NP_859076, Q96IZ6, Q9H9G9, Q9NUI8, Q9P0B5UCSC ID: uc002izv.2RefSeq Accession: NM_181725
Protein: Q96IZ6
(aka MET2A_HUMAN)
CCDS: CCDS45752.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_181725.3
exon count:
9 CDS single in 3' UTR:
no
RNA size:
2519
ORF size:
1137 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
2474.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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