Human Gene FAXC (uc003ppj.4)
  Description: Homo sapiens failed axon connections homolog (Drosophila) (FAXC), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:99,720,793-99,797,531 Size: 76,739 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr6:99,729,040-99,797,248 Size: 68,209 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:99,720,793-99,797,531)mRNA (may differ from genome)Protein (409 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FAXC_HUMAN
DESCRIPTION: RecName: Full=Failed axon connections homolog;
FUNCTION: May play a role in axonal development (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the FAX family.
SEQUENCE CAUTION: Sequence=BAB71576.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.43 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 55.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -161.90283-0.572 Picture PostScript Text
3' UTR -2290.548247-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF10568 - Outer mitochondrial membrane transport complex protein
PF17171 - Glutathione S-transferase, C-terminal domain
PF17172 - Glutathione S-transferase N-terminal domain

SCOP Domains:
47616 - Glutathione S-transferase (GST), C-terminal domain
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q5TGI0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  EnsemblFlyBaseWormBase 
  Protein SequenceProtein SequenceProtein Sequence 
  AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK096480 - Homo sapiens cDNA FLJ39161 fis, clone OCBBF2002357.
BC004869 - Homo sapiens chromosome 6 open reading frame 168, mRNA (cDNA clone MGC:10706 IMAGE:3834272), complete cds.
BC011583 - Homo sapiens chromosome 6 open reading frame 168, mRNA (cDNA clone MGC:20396 IMAGE:4577456), complete cds.
AK057793 - Homo sapiens cDNA FLJ25064 fis, clone CBL04883.
BC006515 - Homo sapiens chromosome 6 open reading frame 168, mRNA (cDNA clone IMAGE:2963854), complete cds.
JF432149 - Synthetic construct Homo sapiens clone IMAGE:100073294 chromosome 6 open reading frame 168 (C6orf168) gene, encodes complete protein.
KJ899807 - Synthetic construct Homo sapiens clone ccsbBroadEn_09201 FAXC gene, encodes complete protein.
AK055101 - Homo sapiens cDNA FLJ30539 fis, clone BRAWH2001255.
JD248982 - Sequence 230006 from Patent EP1572962.
JD557515 - Sequence 538539 from Patent EP1572962.
JD449231 - Sequence 430255 from Patent EP1572962.
JD332672 - Sequence 313696 from Patent EP1572962.
JD315929 - Sequence 296953 from Patent EP1572962.
JD378350 - Sequence 359374 from Patent EP1572962.
JD432237 - Sequence 413261 from Patent EP1572962.
JD392339 - Sequence 373363 from Patent EP1572962.
JD230925 - Sequence 211949 from Patent EP1572962.
KJ903436 - Synthetic construct Homo sapiens clone ccsbBroadEn_12830 FAXC gene, encodes complete protein.
CU679970 - Synthetic construct Homo sapiens gateway clone IMAGE:100019271 5' read C6orf168 mRNA.
JD405863 - Sequence 386887 from Patent EP1572962.
JD475859 - Sequence 456883 from Patent EP1572962.
JD458362 - Sequence 439386 from Patent EP1572962.
JD375777 - Sequence 356801 from Patent EP1572962.
JD143232 - Sequence 124256 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KU39, C6orf168, FAXC_HUMAN, NM_032511, NP_115900, Q5TGI0, Q96F61, Q96LU3, Q9BSS2
UCSC ID: uc003ppj.4
RefSeq Accession: NM_032511
Protein: Q5TGI0 (aka FAXC_HUMAN)
CCDS: CCDS34500.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_032511.2
exon count: 6CDS single in 3' UTR: no RNA size: 9773
ORF size: 1230CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2635.00frame shift in genome: no % Coverage: 99.87
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.