Human Gene LGALS17A (uc021uuo.2)
  Description: Homo sapiens Charcot-Leyden crystal protein pseudogene (LGALS17A), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr19:40,170,014-40,176,058 Size: 6,045 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:40,172,639-40,174,279 Size: 1,641 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:40,170,014-40,176,058)mRNA (may differ from genome)Protein (120 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGeneCardsH-INVLynxMGI
PubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q6ZW74_HUMAN
DESCRIPTION: SubName: Full=Galectin-17A transcription variant 1; SubName: Full=Galectin-17A transcription variant 2; SubName: Full=cDNA FLJ41505 fis, clone BRTHA2009311, moderately similar to EOSINOPHIL LYSOPHOSPHOLIPASE;
SIMILARITY: Contains 1 galectin domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.37 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 8.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.3062-0.134 Picture PostScript Text
3' UTR -545.021779-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR001079 - Galectin_CRD

Pfam Domains:
PF00337 - Galactoside-binding lectin

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases

ModBase Predicted Comparative 3D Structure on Q6ZW74
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030246 carbohydrate binding

Biological Process:
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process


-  Descriptions from all associated GenBank mRNAs
  AK123499 - Homo sapiens cDNA FLJ41505 fis, clone BRTHA2009311, moderately similar to EOSINOPHIL LYSOPHOSPHOLIPASE.
BC118595 - Homo sapiens lectin, galactoside-binding, soluble, 14-like, mRNA (cDNA clone IMAGE:40108147), complete cds.
BC122559 - Homo sapiens lectin, galactoside-binding, soluble, 14-like, mRNA (cDNA clone IMAGE:40108148), complete cds.
BC128606 - Homo sapiens lectin, galactoside-binding, soluble, 14-like, mRNA (cDNA clone MGC:158952 IMAGE:40108149), complete cds.
FJ613354 - Homo sapiens galectin-17A precursor transcription variant 2 (LGALS17A) mRNA, complete cds, alternatively spliced.
FJ613353 - Homo sapiens galectin-17A precursor transcription variant 1 (LGALS17A) mRNA, complete cds, alternatively spliced.
JD240689 - Sequence 221713 from Patent EP1572962.
JD090925 - Sequence 71949 from Patent EP1572962.
JD293505 - Sequence 274529 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC128606, Q6ZW74, Q6ZW74_HUMAN, uc021uuo.1
UCSC ID: uc021uuo.2
RefSeq Accession: NR_034156
Protein: Q6ZW74

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC128606.1
exon count: 3CDS single in 3' UTR: no RNA size: 2018
ORF size: 363CDS single in intron: no Alignment % ID: 99.75
txCdsPredict score: 717.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.