ID:EBLN2_HUMAN DESCRIPTION: RecName: Full=Endogenous Bornavirus-like nucleoprotein 2; AltName: Full=Endogenous Borna-like N element-2; Short=EBLN-2; FUNCTION: May act as a RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human. MISCELLANEOUS: Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.
Glucose James B Meigs et al. BMC medical genetics 2007, Genome-wide association with diabetes-related traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903298]
Framingham 100K SNP data is a resource for association tests of known and novel genes with diabetes and related traits posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 webcite. Framingham 100K data replicate the TCF7L2 association with diabetes.
Insulin James B Meigs et al. BMC medical genetics 2007, Genome-wide association with diabetes-related traits in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903298]
Framingham 100K SNP data is a resource for association tests of known and novel genes with diabetes and related traits posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007 webcite. Framingham 100K data replicate the TCF7L2 association with diabetes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6P2I7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
LF384161 - JP 2014500723-A/191664: Polycomb-Associated Non-Coding RNAs. BC051316 - Homo sapiens hypothetical protein FLJ10213, mRNA (cDNA clone MGC:59764 IMAGE:6214587), complete cds. BC064501 - Homo sapiens hypothetical protein FLJ10213, mRNA (cDNA clone MGC:71205 IMAGE:6215884), complete cds. AY036895 - Homo sapiens GK006 (GK006) mRNA, complete cds. KJ894128 - Synthetic construct Homo sapiens clone ccsbBroadEn_03522 EBLN2 gene, encodes complete protein. AK001075 - Homo sapiens cDNA FLJ10213 fis, clone HEMBA1006474, weakly similar to 40 KD PROTEIN. JD300677 - Sequence 281701 from Patent EP1572962. JD484036 - Sequence 465060 from Patent EP1572962. JD090836 - Sequence 71860 from Patent EP1572962. JD085721 - Sequence 66745 from Patent EP1572962. MA619738 - JP 2018138019-A/191664: Polycomb-Associated Non-Coding RNAs.