Description: Homo sapiens hemopexin (HPX), mRNA. RefSeq Summary (NM_000613): This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]. Transcript (Including UTRs) Position: hg19 chr11:6,452,268-6,462,254 Size: 9,987 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr11:6,452,441-6,462,193 Size: 9,753 Coding Exon Count: 10
ID:HEMO_HUMAN DESCRIPTION: RecName: Full=Hemopexin; AltName: Full=Beta-1B-glycoprotein; Flags: Precursor; FUNCTION: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. SUBUNIT: Interacts with HEV ORF3 protein. Interacts with FLVCR1. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. PTM: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. MISCELLANEOUS: The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity). SIMILARITY: Belongs to the hemopexin family. SIMILARITY: Contains 5 hemopexin-like domains. SEQUENCE CAUTION: Sequence=CAA26382.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P02790
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002639 positive regulation of immunoglobulin production GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0006879 cellular iron ion homeostasis GO:0006898 receptor-mediated endocytosis GO:0015886 heme transport GO:0016032 viral process GO:0020027 hemoglobin metabolic process GO:0042168 heme metabolic process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0051246 regulation of protein metabolic process GO:0060332 positive regulation of response to interferon-gamma GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
X02537 - Human mRNA for serum beta-glycoprotein hemopexin. J03048 - Huma hemopexin mRNA, 3' end. BC005395 - Homo sapiens hemopexin, mRNA (cDNA clone MGC:12533 IMAGE:4071616), complete cds. GQ891443 - Homo sapiens clone HEL-S-164 epididymis secretory sperm binding protein mRNA, complete cds. AK313648 - Homo sapiens cDNA, FLJ94225, highly similar to Homo sapiens hemopexin (HPX), mRNA. JF432450 - Synthetic construct Homo sapiens clone IMAGE:100073661 hemopexin (HPX) gene, encodes complete protein. KJ901496 - Synthetic construct Homo sapiens clone ccsbBroadEn_10890 HPX gene, encodes complete protein. AK303758 - Homo sapiens cDNA FLJ56652 complete cds, highly similar to Hemopexin precursor.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P02790 (Reactome details) participates in the following event(s):
R-HSA-2168884 Ferriheme is transferred from Methemoglobin to Hemopexin R-HSA-2168886 Hemopexin binds Heme b R-HSA-2168887 Ferriheme is transferred from Albumin to Hemopexin R-HSA-2168897 LRP1 (CD91) binds Hemopexin:heme R-HSA-2168880 Scavenging of heme from plasma R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors R-HSA-5653656 Vesicle-mediated transport
US Server
