Human Gene ABHD14A (uc003dco.3)
  Description: Homo sapiens abhydrolase domain containing 14A (ABHD14A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:52,009,042-52,015,216 Size: 6,175 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr3:52,009,152-52,015,034 Size: 5,883 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:52,009,042-52,015,216)mRNA (may differ from genome)Protein (271 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ABHEA_HUMAN
DESCRIPTION: RecName: Full=Alpha/beta hydrolase domain-containing protein 14A; Short=Abhydrolase domain-containing protein 14A; EC=3.-.-.-;
FUNCTION: Possible role in granule neuron development (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Single- pass type II membrane protein (Potential).
SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD14 family.
CAUTION: It is uncertain whether Met-1 or Met-30 is the initiator.
SEQUENCE CAUTION: Sequence=AAQ88568.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.08 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 794.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.20110-0.529 Picture PostScript Text
3' UTR -66.70182-0.366 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00561 - alpha/beta hydrolase fold
PF12697 - Alpha/beta hydrolase family

SCOP Domains:
53474 - alpha/beta-Hydrolases

ModBase Predicted Comparative 3D Structure on Q9BUJ0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016787 hydrolase activity

Cellular Component:
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK298086 - Homo sapiens cDNA FLJ60317 complete cds, highly similar to Aminoacylase-1 (EC 3.5.1.14).
AK294015 - Homo sapiens cDNA FLJ60467 complete cds, moderately similar to Aminoacylase-1 (EC 3.5.1.14).
BC002571 - Homo sapiens abhydrolase domain containing 14A, mRNA (cDNA clone MGC:2481 IMAGE:3143135), complete cds.
AY358201 - Homo sapiens clone DNA92245 SRSQ1913 (UNQ1913) mRNA, complete cds.
AK308592 - Homo sapiens cDNA, FLJ98633.
AL050015 - Homo sapiens mRNA; cDNA DKFZp564O243 (from clone DKFZp564O243).
EU832421 - Synthetic construct Homo sapiens clone HAIB:100067450; DKFZo004F1128 abhydrolase domain containing 14A protein (ABHD14A) gene, encodes complete protein.
EU832336 - Synthetic construct Homo sapiens clone HAIB:100067365; DKFZo008F1127 abhydrolase domain containing 14A protein (ABHD14A) gene, encodes complete protein.
KJ898561 - Synthetic construct Homo sapiens clone ccsbBroadEn_07955 ABHD14A gene, encodes complete protein.
JD293879 - Sequence 274903 from Patent EP1572962.
JD410513 - Sequence 391537 from Patent EP1572962.
JD320757 - Sequence 301781 from Patent EP1572962.
JD117603 - Sequence 98627 from Patent EP1572962.
JD334737 - Sequence 315761 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ABHEA_HUMAN, NM_015407, NP_056222, Q6UXU8, Q9BUJ0, Q9Y3T7, UNQ1913/PRO4373
UCSC ID: uc003dco.3
RefSeq Accession: NM_015407
Protein: Q9BUJ0 (aka ABHEA_HUMAN)
CCDS: CCDS2843.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015407.4
exon count: 5CDS single in 3' UTR: no RNA size: 1118
ORF size: 816CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1808.00frame shift in genome: no % Coverage: 99.11
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.