Human Gene TMEM174 (uc010izc.3)
  Description: Homo sapiens transmembrane protein 174 (TMEM174), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:72,469,023-72,470,970 Size: 1,948 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr5:72,469,071-72,469,992 Size: 922 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:72,469,023-72,470,970)mRNA (may differ from genome)Protein (243 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM174_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 174;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM174
Diseases sorted by gene-association score: renal cell carcinoma, papillary (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.29 RPKM in Kidney - Cortex
Total median expression: 6.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.6048-0.200 Picture PostScript Text
3' UTR -309.78978-0.317 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15029 - Transmembrane protein 174

ModBase Predicted Comparative 3D Structure on Q8WUU8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC019346 - Homo sapiens transmembrane protein 174, mRNA (cDNA clone MGC:13034 IMAGE:3613225), complete cds.
AK315460 - Homo sapiens cDNA, FLJ96519.
AK055830 - Homo sapiens cDNA FLJ31268 fis, clone KIDNE2006062.
JF432630 - Synthetic construct Homo sapiens clone IMAGE:100073867 transmembrane protein 174 (TMEM174) gene, encodes complete protein.
KJ895497 - Synthetic construct Homo sapiens clone ccsbBroadEn_04891 TMEM174 gene, encodes complete protein.
JD082854 - Sequence 63878 from Patent EP1572962.
JD234848 - Sequence 215872 from Patent EP1572962.
JD388554 - Sequence 369578 from Patent EP1572962.
JD481871 - Sequence 462895 from Patent EP1572962.
JD241992 - Sequence 223016 from Patent EP1572962.
JD175397 - Sequence 156421 from Patent EP1572962.
JD257263 - Sequence 238287 from Patent EP1572962.
JD342776 - Sequence 323800 from Patent EP1572962.
JD135517 - Sequence 116541 from Patent EP1572962.
JD303282 - Sequence 284306 from Patent EP1572962.
JD477159 - Sequence 458183 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RDA0, NM_153217, NP_694949, Q8WUU8, Q96N81, TM174_HUMAN
UCSC ID: uc010izc.3
RefSeq Accession: NM_153217
Protein: Q8WUU8 (aka TM174_HUMAN)
CCDS: CCDS4018.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_153217.2
exon count: 2CDS single in 3' UTR: no RNA size: 1758
ORF size: 732CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1664.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.