ID:THAP5_HUMAN DESCRIPTION: RecName: Full=THAP domain-containing protein 5; FUNCTION: May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. SUBUNIT: Interacts with HTRA2; under apoptotic conditions. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in the heart. Also found in brain and skeletal muscle. PTM: Cleaved by HTRA2 during apoptosis. SIMILARITY: Contains 1 THAP-type zinc finger. SEQUENCE CAUTION: Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAL24383.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z6K1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
